Quantitative EEG of Rapid-Eye-Movement Sleep: A Marker of Amnestic Mild Cognitive Impairment

Clinical EEG and Neuroscience
Pauline BrayetJ Montplaisir

Abstract

The basal forebrain cholinergic system, which is impaired in early Alzheimer's disease, is more crucial for the activation of rapid-eye-movement (REM) sleep electroencephalogram (EEG) than it is for wakefulness. Quantitative EEG from REM sleep might thus provide an earlier and more accurate marker of the development of Alzheimer's disease in subjects with mild cognitive impairment (MCI) subjects than that from wakefulness. To assess the superiority of the REM sleep EEG as a screening tool for preclinical Alzheimer's disease, 22 subjects with amnestic MCI (a-MCI; 63.9±7.7 years), 10 subjects with nonamnestic MCI (na-MCI; 64.1±4.5 years) and 32 controls (63.7±6.6 years) participated in the study. Spectral analyses of the waking EEG and REM sleep EEG were performed and the [(delta+theta)/(alpha+beta)] ratio was used to assess between-group differences in EEG slowing. The a-MCI subgroup showed EEG slowing in frontal lateral regions compared to both na-MCI and control groups. This EEG slowing was present in wakefulness (compared to controls) but was much more prominent in REM sleep. Moreover, the comparison between amnestic and nonamnestic subjects was found significant only for the REM sleep EEG. There was no difference in EEG powe...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Vazquez, H A Baghdoyan
Jul 4, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M GrunwaldH J Gertz
Mar 8, 2002·Alzheimer Disease and Associated Disorders·Martin GrunwaldHerman-Josef Gertz
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Dec 27, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Jul 15, 2006·Experimental Gerontology·Lisa MosconiMony J de Leon
Dec 28, 2006·Neurology·A BusseS G Riedel-Heller
Jan 16, 2007·Neurobiology of Aging·Lisa MosconiMony J de Leon
Jul 3, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K van der HieleH A M Middelkoop
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroshi Matsuda
Jan 19, 2008·Neuropsychologia·Karl HerholzE Kalbe
Jun 10, 2008·International Journal of Geriatric Psychiatry·Christian LuckhausJürgen Brinkmeyer
Jul 4, 2008·Neuroreport·Géraldine RauchsPeter Anderer
Nov 11, 2008·Journal of Alzheimer's Disease : JAD·Davide Vito MorettiGiovanni Battista Frisoni
Dec 17, 2009·Archives of Neurology·Ronald C PetersenClifford R Jack
May 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pascali Durand-MartelNancy Paquet
Oct 22, 2010·Neurobiology of Aging·Cathleen HaenseWolf-Dieter Heiss
Oct 6, 2011·Journal of Alzheimer's Disease : JAD·Valeria DragoGiovanni B Frisoni
Feb 4, 2012·Journal of the International Neuropsychological Society : JINS·Carmen E WesterbergKen A Paller
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Medalla, Helen Barbas
Dec 19, 2012·Frontiers in Neurology·Stuart FogelJulie Carrier
Aug 7, 2013·European Archives of Psychiatry and Clinical Neuroscience·Jing Ming YeoSuvankar Pal
Sep 5, 2013·Journal of Alzheimer's Disease : JAD·Guido GainottiCamillo Marra
Sep 18, 2013·CNS & Neurological Disorders Drug Targets·Filippo CaraciSanto Di Nuovo
Aug 26, 2014·Journal of Alzheimer's Disease : JAD·Stephen W ScheffElliott J Mufson
Dec 3, 2014·Neurobiology of Aging·Véronique LatreilleJean-François Gagnon
Dec 3, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·John T O'BrienJim Lloyd

❮ Previous
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Citations

Feb 26, 2016·Brain : a Journal of Neurology·Véronique LatreilleJean-François Gagnon
Apr 7, 2017·Neuron·Bryce A ManderMatthew P Walker
May 16, 2017·Current Opinion in Neurobiology·Oleg I LyaminJerome M Siegel
Dec 24, 2017·Scientific Reports·Péter P UjmaMartin Dresler
Mar 7, 2018·Journal of Sleep Research·Ina DjonlagicSusan Redline
Aug 14, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chanung Wang, David M Holtzman
Mar 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Feng ZhangWeidong Le
Dec 7, 2019·Neuroscience Bulletin·Chao HeChenggang Jiang
Oct 2, 2019·International Journal of Environmental Research and Public Health·Serena ScarpelliLuigi De Gennaro
May 28, 2020·Frontiers in Aging Neuroscience·Victoria M PakFannie Onen
Nov 19, 2019·Current Sleep Medicine Reports·Michael K Scullin, Chenlu Gao
Jan 26, 2017·Frontiers in Behavioral Neuroscience·Lorenz HärtnerThomas Fenzl
May 22, 2018·Journal of Alzheimer's Disease : JAD·Andreia G AndradeRicardo S Osorio
Aug 2, 2018·Frontiers in Psychology·Alejandra Rosales-LagardeJose S Lopez-Noguerola
May 2, 2018·Journal of Alzheimer's Disease : JAD·Paola ProserpioLino Nobili
Oct 20, 2020·Frontiers in Neuroscience·Bryce A Mander
Apr 18, 2020·Sleep Medicine Reviews·Angela L D'RozarioSharon L Naismith

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