PMID: 75285Jan 15, 1978Paper

Quantitative estimation of cationic leukocyte antigen (cla) and lysozyme in leukaemic leukocytes (author's transl)

Klinische Wochenschrift
H R Böhm, F W Tischendorf

Abstract

Cationic lysosomal proteins such as cationic leukocyte antigen (CLA) and lysozyme were estimated in leukocyte lysates of acute and chronic leukaemics using quantitative enzymatic and immunoprecipitation techniques. The studies demonstrate that both lysosomal conponents are markers of non-lymphatic leukaemias. Therefore the determination of CLA and lysozyme is valuable for the differential diagnosis of acute leukaemias. The intracellular cationic protein contents showed characteristic kinetic variations as showing during X-irradiation of the spleen in cases of chronic myelocytic leukaemia. White cells in leukocytosis could be distinguished from normals by remarkably low cationic protein contents in leukocyte lysates. The results are interpreted in the light of current results revealed by immunofluorescent analyses.

References

May 1, 1972·The Journal of Clinical Investigation·N E HansenK Olgaard
May 1, 1973·British Journal of Haematology·N E Hansen, V Andersen
Jun 1, 1971·British Journal of Haematology·H AsamerH Braunsteiner
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
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Dec 1, 1963·The Journal of Experimental Medicine·Z A COHN, E WIENER

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