PMID: 7539901Feb 17, 1995Paper

Quantitative evaluation of calcitonin gene-related peptide and substance P levels in rat spinal cord following peripheral nerve injury

Neuroscience Letters
K C Kajander, J Xu

Abstract

Levels of calcitonin gene-related peptide immunoreactivity (CGRP-ir) and substance P immunoreactivity (SP-ir) in the lumbar dorsal spinal cord of rats with either sciatic nerve transection or chronic constriction injury (CCI) were measured using radioimmunoassay. Significant decreases in CGRP-ir and SP-ir occurred in the ipsilateral spinal cord at 10 and 31 days after nerve transection. An ipsilateral decrease in SP-ir occurred 60 days after CCI. In addition, contralateral decreases in CGRP-ir and SP-ir occurred 31 days after transection and 60 days after CCI. Transection of the sciatic nerve produced greater decreases in peptide levels than did the CCI. Changes in spinal levels of these peptides may be involved in the appearance of neuropathic signs associated with nerve injury.

References

Jul 1, 1941·Journal of Neurology and Psychiatry·G WeddellE Gutmann

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Citations

Aug 10, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T NaraF Goto
Nov 8, 2001·European Journal of Pharmacology·D H VrintenW H Gispen
Oct 24, 1998·The European Journal of Neuroscience·A PopratiloffA Rustioni
Aug 19, 2008·The Journal of Pain : Official Journal of the American Pain Society·Mei XuCharles Chavkin
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Bradley K Taylor, Kenneth E McCarson
Mar 17, 1997·The Journal of Comparative Neurology·A A CameronS M Carlton
Apr 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wei WangYun-Qing Li
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Feb 28, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Dianying ZhangBaoguo Jiang

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