Quantitative evaluation of coat-color patterns in artificially produced chimeras of the mouse by means of a microcomputer-based video-image analysis system

Developmental Genetics
C Tachi

Abstract

The possible application of microcomputer-based video-image analysis systems for the quantitative description of coat-color patterns in artificially produced chimeras and genetic mosaics of mice was investigated using a program developed by the author. This system is capable of extracting, from sampled images of pelts, the morphometric image features as defined by Pratt [1978] that are essential to the quantitative description of coat-color patterns in these animals. It does so with reasonable accuracy and speed and at low cost. No description of any similar system has been published in the literature. Performance of our system is described using C3H/HeJ----BALB/c chimeras as examples. The complex phenotypic expression of hair pigmentation in mice makes the use of a video-image analysis system like this one essential to evaluate the morphometric parameters of the patterns (e.g., the mixing ratios between the two components, the number of different-colored stripes, etc.) more precisely and reproducibly than has been done yet in the literature. The results indicate that the number of melanoblast clones in mice, as estimated from the number of minimal recognizable stripes (MRS), might be considerably larger than previously indicat...Continue Reading

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