PMID: 1222432Jan 1, 1975Paper

Quantitative evaluation of coronary perfusion in man

Catheterization and Cardiovascular Diagnosis
F J Klocke


The usefulness and limitations of currently available techniques for quantitating coronary flow in ischemic heart disease are summarized. There are appreciable difficulties in assessing coronary flow solely from an arteriographic evaluation of the epicardial arteries. There is a considerable reserve mechanism for vasodilation at the arteriolar level, and a proximal occlusive lesion produces a reduction in flow only after this distal reserve has been exhausted. In addition, small increments in the severity of established lesions sometimes cause profound reductions in flow. The development of clinically useful flow measurements has been impeded by methodological problems related to nonuniformity of flow within the left ventricle in coronary artery disease. Validation of specific techniques for abnormal situations is difficult but possible and should probably be a prerequisite to the clinical application of any technique. When a methodologically appropriate technique is employed, average left ventricular flow per unit weight is found to be reduced systematically at rest in patients with double- and triple-vessel disease. This reduction is a group difference, however, and is not always evident in individual patients. Accordingly, m...Continue Reading


Jan 1, 1974·The Journal of Clinical Investigation·K L MelmonS Bauminger
Apr 1, 1972·The Journal of Clinical Investigation·P J CannonE M Dwyer
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Mar 1, 1967·Journal of Applied Physiology·P L McHenry, S B Knoebel
Feb 1, 1974·The Journal of Clinical Investigation·D Mymin, G P Sharma


Oct 1, 1978·British Journal of Clinical Pharmacology·R H Swanton, D J Coltart
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Beat H WalpothOtto M Hess
Jan 1, 1979·Catheterization and Cardiovascular Diagnosis·A S Iskandrian, B L Segal

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