Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach.

Journal of the American College of Cardiology
Daniel G KramerJ E Udelson

Abstract

The purpose of this study was to quantitatively assess the relationship between therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in patients with left ventricular dysfunction (LVD). Whether therapy-induced changes in left ventricular ejection fraction (LVEF), end-diastolic volume (EDV), and end-systolic volume (ESV) are predictors of mortality in patients with LVD is not established. Searches for randomized controlled trials (RCTs) were conducted to identify drug or device therapies for which an effect on mortality in patients with LVD was studied in at least 1 RCT of > or = 500 patients (mortality trials). Then, all RCTs involving those therapies were identified in patients with LVD that described changes in LVEF and/or volumes over time (remodeling trials). We examined whether the magnitude of remodeling effects is associated with the odds ratios for death across all therapies or associated with whether the odds ratio for mortality was favorable, neutral, or adverse (i.e., statistically significantly decreased, nonsignificant, or statistically significantly increased odds for mortality, respectively). Included were 30 mortality trials of 25 drug/device therapies (n = 69,766 patients; median...Continue Reading

Associated Clinical Trials

References

Jul 15, 1992·The American Journal of Cardiology·C O GøtzscheK Thygesen
Sep 1, 1990·The American Journal of Cardiology·S G PollockM L Smucker
Jun 1, 1990·Clinical Cardiology·G J HaasC V Leier
Dec 1, 1989·Journal of the American College of Cardiology·A W HamerJ A Johns
Aug 14, 1987·The American Journal of Cardiology·G ZipperleF Heinrich
Jul 14, 1988·The New England Journal of Medicine·M A PfefferE Braunwald
Jan 1, 1985·Journal of the American College of Cardiology·J A FranciosaR A Jordan
Oct 1, 1985·British Heart Journal·B P McGrathC I Johnston
Jul 11, 1988·The American Journal of Cardiology·J N Cohn, T S Rector
Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 1, 1980·The American Journal of Cardiology·W S ColucciE Braunwald
May 1, 1995·Journal of the American College of Cardiology·S L OlsenM R Bristow
Mar 1, 1993·British Heart Journal·S G RayS M Cobbe

❮ Previous
Next ❯

Citations

Jan 6, 2011·Current Heart Failure Reports·Miriam S Jacob, W H Wilson Tang
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eleonora MezzaromaAntonio Abbate
Mar 11, 2011·European Heart Journal·Gerd Hasenfuss, John R Teerlink
Nov 20, 2013·The New England Journal of Medicine·Michael A AckerUNKNOWN CTSN
Jan 1, 2013·Clinical Investigation·Kory J Lavine, Douglas L Mann
Aug 31, 2014·Revista Española De Cardiología·Eduardo Pozo, Javier Sanz
Nov 5, 2015·European Heart Journal·Barry A Borlaug
Nov 10, 2015·The New England Journal of Medicine·Daniel GoldsteinUNKNOWN CTSN
Jan 27, 2016·The International Journal of Cardiovascular Imaging·Jonathan R Weir-McCallJ Graeme Houston
Jan 23, 2016·Progress in Cardiovascular Diseases·Anupam Basuray, James C Fang
Jun 22, 2015·European Heart Journal·G Michael Felker
Sep 1, 2015·Stem Cell Research & Therapy·Marko BanovicJozef Bartunek
Oct 15, 2011·Journal of the American College of Cardiology·William H Gaasch, Michael R Zile
Mar 19, 2011·Trends in Pharmacological Sciences·Michael J A Walker
Apr 26, 2016·Journal of Cardiac Failure·Abhishek JaiswalThierry H le Jemtel
May 14, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ulrich Schäfer
Jan 18, 2007·Archives of Medical Research·Karina GiubertiIvanita Stefanon
Nov 6, 2012·Journal of the American College of Cardiology·Horng H ChenJohn C Burnett
Dec 20, 2016·Future Cardiology·Konstantinos ChouchoulisDimitrios Alexopoulos
Mar 4, 2017·JACC. Heart Failure·James E Udelson
Jan 4, 2017·Journal of the American College of Cardiology·David W M MullerUNKNOWN Tendyne Global Feasibility Trial Investigators
Mar 31, 2017·Current Atherosclerosis Reports·Nishant Krishna SekaranSunil V Rao
Apr 9, 2016·Journal of the American College of Cardiology·Michael R GoldDouglas L Mann
May 5, 2018·Expert Review of Medical Devices·Judith E LowryKlaus K Witte
Mar 25, 2016·World Journal of Transplantation·Christos D KontogiannisJohn N Nanas
Oct 21, 2017·JRSM Cardiovascular Disease·Upasana Tayal, Sanjay K Prasad
Jun 8, 2018·Clinical Pharmacology in Drug Development·Friederike KanefendtChristiane Otto
Jun 29, 2018·Journal of Cardiovascular Medicine·Serenella CastelvecchioLorenzo Menicanti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.