Quantitative evaluation of early retinal changes in children with type 1 diabetes mellitus without retinopathy

Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Kemal TekinZehra Aycan

Abstract

To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) caused the thinning in retinal layers in children with type 1 DM without retinopathy by using spectral domain optical coherence tomography (SD-OCT) and to compare the results obtained with those in healthy children. This cross-sectional prospective study included 73 patients with type 1 DM (DM group) and 62 age-matched control subjects (control group). The duration of DM and the glycosylated haemoglobin (HbA1c) levels of the diabetic children were recorded. Macular and peripapillary retinal nerve fibre layer (RNFL) thickness measurements obtained by SD-OCT were compared. There were significant differences in the mean values of the temporal inner, temporal outer and inferior outer macular thickness measurements between the groups (p = 0.031, p = 0.028 and p = 0.039, respectively). Moreover, the children with type 1 DM showed significantly thinner global, temporal superior and nasal inferior RNFL thickness measurements compared to the controls (p = 0.035, p = 0.022 and p = 0.034, respectively). Additionally, both the mean duration of DM and the mean HbA1c values were inversely and statistically significantly correlated with the mean temporal...Continue Reading

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May 22, 2017·American Journal of Ophthalmology·Kemal TekinZehra Aycan

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Citations

Apr 16, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Muhammed ŞahinFatih Mehmet Türkcü
Jul 24, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Semra Tiryaki DemirDilek Guven
May 10, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Kemal TekinMustafa Koc
Jun 25, 2021·Korean Journal of Ophthalmology : KJO·Ismail Mohd-IlhamIsmail Shatriah

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