PMID: 7539592May 1, 1995Paper

Quantitative evaluation of flow dynamics of erythrocytes in microvessels: influence of erythrocyte aggregation

The American Journal of Physiology
M SoutaniN Maeda

Abstract

Effects of erythrocyte aggregation on the flow dynamics of erythrocytes in microvessels were examined quantitatively by perfusing human erythrocytes suspended in isotonic medium containing various concentrations of dextran (70,400 avg mol wt, Dx-70) into a part of the microvascular bed isolated from rabbit mesentery. Thickness of the marginal cell-free layer was measured with an image analyzer, total flow resistance was determined on the basis of the perfusion pressure-volume flow relationship, and homogeneity of erythrocyte flow was evaluated by the power spectrum obtained by the fast Fourier transform of the light intensity change monitored on single microvessels. With increasing dextran concentration, suspension viscosity of erythrocytes at high shear rates increased linearly and thickness of the cell-free layer increased in a sigmoidal fashion. Flow resistance increased relatively little over the range of dextran concentrations in which the cell-free layer increased most rapidly. Furthermore, the flow pattern of erythrocytes in microvessels became inhomogeneous. In conclusion, the present study shows that Dx-70-induced erythrocyte aggregation results in increased flow resistance in the circulatory system, even through the w...Continue Reading

Citations

Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K OsterlohA R Pries
Sep 27, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Oguz K BaskurtHerbert J Meiselman
Aug 10, 2006·Journal of Mathematical Biology·Wensheng Zhang, Aurélie Edwards
May 29, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sangho KimPaul C Johnson
May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Iwona CichaNobuji Maeda
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Tim WattsGerard B Nash
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·N TateishiN Maeda
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R B AmiS Yedgar
Jun 21, 2014·PloS One·Joseph M SherwoodStavroula Balabani
Nov 8, 2014·Biomicrofluidics·Eunseop YeomSang-Joon Lee
Apr 25, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yoshiharu FujimoriTaku Imai
Jul 13, 2019·Biomechanics and Modeling in Mechanobiology·L L XiaoW W Yan
Mar 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Peng Kai OngSangho Kim
Jul 28, 2020·PLoS Computational Biology·William Davis HaseldenPatrick J Drew

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