Quantitative evaluation of human cerebellum-dependent motor learning through prism adaptation of hand-reaching movement

PloS One
Yuji HashimotoKinya Ishikawa

Abstract

The cerebellum plays important roles in motor coordination and learning. However, motor learning has not been quantitatively evaluated clinically. It thus remains unclear how motor learning is influenced by cerebellar diseases or aging, and is related with incoordination. Here, we present a new application for testing human cerebellum-dependent motor learning using prism adaptation. In our paradigm, the participant wearing prism-equipped goggles touches their index finger to the target presented on a touchscreen in every trial. The whole test consisted of three consecutive sessions: (1) 50 trials with normal vision (BASELINE), (2) 100 trials wearing the prism that shifts the visual field 25° rightward (PRISM), and (3) 50 trials without the prism (REMOVAL). In healthy subjects, the prism-induced finger-touch error, i.e., the distance between touch and target positions, was decreased gradually by motor learning through repetition of trials. We found that such motor learning could be quantified using the "adaptability index (AI)", which was calculated by multiplying each probability of [acquisition in the last 10 trials of PRISM], [retention in the initial five trials of REMOVAL], and [extinction in the last 10 trials of REMOVAL]....Continue Reading

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Citations

Jul 12, 2019·PLoS Computational Biology·Emma D WilsonJohn Porrill
Jun 4, 2020·Scientific Reports·Karolina LöwgrenAnders Rasmussen
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Takeru HondaMasao Ito
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Aug 25, 2020·Clinical Biomechanics·Amanda E Stone, Chris J Hass
Apr 10, 2021·Journal of the Neurological Sciences·Meng-Ling ChenSheng-Han Kuo
Dec 19, 2017·Neuropsychologia·Pierre PetitetJacinta O'Shea

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Software Mentioned

REMOVAL
Visual Reaching Task
R
GraphPad
Matlab
BASELINE
KATANO TOOL SOFTWARE
Windows
LabVIEW2011
GraphPad Prism

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