PMID: 6540229Jul 1, 1984Paper

Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J De CeaurrizJ P Guenier

Abstract

A decrease in respiratory rate resulting from irritation of upper airways and a decrease in duration of immobility in a 'behavioural despair' swimming test occurred in mice during and following short-term inhalation exposures to some commonly used aliphatic ketones. Linear concentration-effect relationships were obtained that allowed two different median active levels (MALs) to be calculated. MALs that produced a 50% decrease in respiratory rate (RD50) were calculated as indicators of the sensory irritation potency of diisobutyl ketone, mesityl oxide, methyl amyl ketone, methyl isoamyl ketone and methyl propyl ketone. MALs that produced a 50% decrease in immobility (ID50) were determined for acetone, isophorone, mesityl oxide, methyl amyl ketone, methyl isoamyl ketone, methyl isobutyl ketone and methyl propyl ketone. The systematic determination of MALs permits classification of ketones in terms of their relative potencies for eliciting a given effect. The lowest MAL indicates the primary manifestation of toxicity, against which protection should be taken. MALs associated with such critical responses may be useful in the establishment of safe levels of occupational exposure to ketones, a conclusion supported by the linear relat...Continue Reading

References

Mar 1, 1979·American Industrial Hygiene Association Journal·L E KaneY Alarie
Jul 1, 1978·American Industrial Hygiene Association Journal·M L Woebkenberg, L J Doemeny
Feb 1, 1973·Toxicology and Applied Pharmacology·Y Alarie
Oct 1, 1966·Archives of Environmental Health·Y Alarie
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·D Couri, M Milks
Oct 1, 1981·Toxicology Letters·J C de CeaurrizJ P Guenier
Dec 1, 1981·Environmental Health Perspectives·Y Alarie
Jun 1, 1980·American Industrial Hygiene Association Journal·L E KaneY Alarie

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Citations

Apr 1, 1990·Journal of Applied Toxicology : JAT·M T BrondeauJ de Ceaurriz
Jun 20, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·P PrazadA Gulati
Jan 1, 1991·Critical Reviews in Toxicology·G D Nielsen
Jan 1, 1991·Critical Reviews in Toxicology·P M BosP C Bragt
May 28, 2004·International Journal of Toxicology·Wilbur Johnson
Jan 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Jun 27, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang

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