Quantitative evaluation of SPECT with FP-CIT. Importance of the reference area

Revista española de medicina nuclear
S J Ortega LozanoJ M Jiménez-Hoyuela

Abstract

The aim of this study is to compare several uptake indexes between specific and non-specific activity to determine the existence of degenerative Parkinsonism according to different reference areas. A total of 46 patients (23 men and 23 women), randomly selected from individuals referred to our center with a movement disorder, were included in the study. Mean age was 70.2 ± 10.2 years (41-87). The uptake indexes were obtained through the areas of interest (ROIs) located in the striate (specific uptake) and other reference ROIs located in areas with different concentrations of serotonin receptors: low-cerebellum, medium-occipital cortex and high-midbrain. A high linear correlation was found between indexes having low and medium concentration of serotonin receptors. The ROC curve analysis shows an area under the curve of 0.874, 0.886 and 0.739 and regression coefficients of 5.41, 6.62 and 3.41, respectively for the striatum/cerebellum (E/C), striatum/occipital (E/O) and striatum midbrain (E/M) indexes. Optimal cutoff for E/O (1.35), index with the best behavior, provides a sensitivity of 0.84 and specificity of 0.89. The reference area selected may alter the predictive power of the different indexes to determine the existence of a...Continue Reading

References

Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·T S BenamerV Ries
Jul 13, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·J R SlaughterM P Martens
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Christopher H van DyckRobert B Innis
Oct 31, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Christoph Scherfler, Michael Nocker

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Citations

Oct 9, 2012·Medical Physics·I A IllanS J Ortega Lozano
Dec 1, 2017·Frontiers in Neuroinformatics·Francisco J Martinez-MurciaDiego Salas-Gonzalez
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Eugene JeongJae Gol Choe

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