PMID: 9437245Oct 1, 1994Paper

Quantitative evaluations of gap junctions in old rat brown adipose tissue after cold acclimation: a freeze-fracture and ultra-structural study

Tissue & Cell
G BarbatelliS Cinti

Abstract

The morphological and functional modifications of brown adipose tissue (BAT), the tissue responsible for non-shivering thermogenesis, are well established during the phases of active stimulation (i.e. neonatal period and cold acclimation) in young animals. The 'active' brown adipocytes are filled with numerous small lipid vacuoles and large mitochondria packed with cristae rich in the protonophore uncoupling protein (UCP), whereas the 'quiescent' cell shows larger, confluent vacuoles and smaller mitochondria with rarefied cristae poor of the uncoupling protein. It is well known from literature that also gap junctions (gjs), responsible for the electrical coupling among adjacent adipocytes, modify their size following the physiological stimulus in young animals. This is in agreement with the morphology of the functionally active brown adipocyte, i.e. the multilocular, UCP-positive cell. Although the presence of the BAT in old animals is well documented, less is known about its reactivity to physiological stimuli. The present work demonstrates that after cold acclimation brown adipocytes of old rats (2 years) change their ultrastructure in a similar way as in young rats. A quantitative analysis of gap junction areas on replicas o...Continue Reading

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Citations

Jan 1, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Damian Seung-ho ShinLeslie Thomas Buck
Oct 30, 2001·The Proceedings of the Nutrition Society·S Cinti
Nov 18, 2000·Eating and Weight Disorders : EWD·S Cinti
Mar 12, 2016·Nature Reviews. Drug Discovery·Antonio GiordanoSaverio Cinti

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