Quantitative evidence of intestinal colonization by Clostridium botulinum in four cases of infant botulism

The Journal of Infectious Diseases
B W WilckeS S Arnon

Abstract

Infant botulism is an infectious form of a disease heretofore principally known as food-borne intoxication. Previous epidemiologic and laboratory studies have shown that infant botulism results from the ingestion of spores of Clostridium botulinum that subsequently germinate in the infant intestine and produce botulinal toxin. A quantitative study of the fecal microflora of four infants with infant botulism revealed the presence of C. botulinum in numbers as high as 6.0 x 10(8) colony-forming units (cfu)/g. At various times after the onset of illness, the numbers of C. botulinum that were recovered from feces ranged from 10(3) to 10(8) cfu/g and constituted from 0.01% to 3.3% of the total fecal flora. It was concluded that the large numbers of C. botulinum found in patients' feces could occur only as a consequence of in vivo spore germination and outgrowth.

Citations

Dec 24, 1997·Toxicon : Official Journal of the International Society on Toxinology·L B PearceA Gupta
Aug 15, 1985·The New England Journal of Medicine·J Dequeker, P Geusens
Feb 3, 2006·The New England Journal of Medicine·Stephen S ArnonCharles L Hatheway
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L FeniciaP Aureli
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Lance L Simpson
Dec 1, 1983·American Journal of Public Health·J G MorrisR A Feldman
Oct 1, 1990·Japanese Journal of Medical Science & Biology·H NakanoG Sakaguchi
Dec 1, 1990·Japanese Journal of Medical Science & Biology·M TakahashiG Sakaguchi
Apr 29, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V GodartP Lepage
Jul 1, 1990·The American Journal of Emergency Medicine·A Jagoda, G Renner
Aug 2, 2000·Journal of Child Neurology·R H SandlerH M Wexler
Nov 1, 1993·Clinical Pediatrics·J M Wigginton, P Thill
Nov 26, 2015·Microbiome·T Brian ShireyBrian H Raphael
Nov 19, 2020·Toxins·Christine Rasetti-EscargueilMichel R Popoff
Mar 1, 1981·Journal of Clinical Microbiology·M DezfulianV R Dowell
Apr 1, 1996·Clinical Microbiology Reviews·T F Midura
Aug 1, 1983·Infection and Immunity·C L Wells, E Balish
Jan 1, 1982·Journal of Clinical Microbiology·J C PatonJ I Manson

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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