Abstract
The pathogenesis and interrelationships of neuroendocrine lung carcinomas are not well understood. Tissue macro-arrays prepared from surgical resection specimens from 35 patients with typical carcinoid (TC), six with atypical carcinoid (AC), 13 with large cell neuroendocrine carcinoma (LCNEC), and 15 with small cell lung carcinoma (SCLC) were investigated by fluorescence in situ hybridization (FISH) and immunohistochemistry. Hybridizations with locus-specific DNA probes demonstrated a high incidence of deletion for the tumour suppressor genes p53 and retinoblastoma (Rb), and for the oncogene cyclin D1, comparable in all carcinoma types. Similarly, an increase of DNA copy number for the Her-2/neu and c-myc oncogenes was noted in all neoplasms. A more detailed quantitative analysis of the results, however, demonstrated increasing numbers of cells harbouring these genomic alterations, from low-grade TC to highly malignant SCLC, with the exception of cyclin D1 deletion. Mutations of the p53 and Rb genes, as assayed by immunohistochemical studies, were observed at high incidence in high-grade carcinomas, compared with a low incidence in the low-grade carcinomas. Conversely, in all carcinoma types, neither membrane-bound Her-2/neu no...Continue Reading
References
Apr 1, 1995·The Journal of Pathology·D G WangK D Buchanan
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·V GouyerC Brambilla
Jun 1, 1994·Human Pathology·R A DeLellis
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·I E SchauerR A Sclafani
May 4, 1994·Journal of the National Cancer Institute·H J XuW F Benedict
Feb 1, 1996·British Journal of Cancer·D C BetticherN Thatcher
Jul 15, 1996·Cancer Genetics and Cytogenetics·T TaguchiJ R Testa
Mar 21, 1998·Human Molecular Genetics·L V DebelenkoM R Emmert-Buck
Sep 18, 1998·Cancer·A KovatichP A McCue
Feb 23, 1999·The American Journal of Pathology·B GörtzP Komminoth
Mar 17, 1999·American Journal of Clinical Pathology·J L Wisecarver
Mar 26, 1999·Cancer·N OnukiA F Gazdar
Jun 22, 1999·British Journal of Cancer·T MishinaY Kawakami
Aug 26, 1999·The British Journal of Ophthalmology·J M MAcKENZIE
Mar 30, 2000·Genes, Chromosomes & Cancer·L V DebelenkoM R Emmert-Buck
Citations
Jul 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kanika A BowenB Mark Evers
Jul 25, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenzo HiroshimaYukio Nakatani
Apr 16, 2005·The American Journal of Surgical Pathology·Hind NassarDavid S Klimstra
Jan 18, 2008·Pathology International·Randa Mahmoud Sobhi AminYukio Nakatani
Jun 9, 2004·Journal of Clinical Microbiology·Hiroaki TakeuchiMutsuo Takahashi
Jul 4, 2003·Annals of Surgical Oncology·R HageJ M M van den Bosch
Jul 12, 2014·Journal of Cancer Research and Clinical Oncology·Rita de Cássia S AlvesAdriana Vial Roehe
Nov 1, 2006·American Journal of Clinical Pathology·Anna Fen-Yau LiJeou-Yuan Chen
Apr 10, 2004·Cancer Science·Yasuhito KobayashiEiju Tsuchiya
Aug 2, 2006·Histopathology·J M GiltnaneB L King
Feb 1, 2011·Cancer Science·Masaki KimuraTakehiko Kamijo
Jan 11, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wei-Xia PengTakashi Nakajima
Aug 11, 2004·Experimental Cell Research·Zoltan WienerThomas Brunner
Aug 30, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Colin S CooperShu-Jun Cheng
Aug 29, 2006·Seminars in Cancer Biology·Marina Vita, Marie Henriksson
May 17, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenzo HiroshimaTakeshi Horai
Jul 24, 2007·The Annals of Thoracic Surgery·Akira IyodaTakehiko Fujisawa
Mar 6, 2008·The Journal of Medical Investigation : JMI·Yoshio OkanoFumitaka Ogushi
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giulio RossiElisabeth Brambilla
Aug 1, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M Massoni NetoV L Capelozzi
Dec 23, 2006·Seminars in Thoracic and Cardiovascular Surgery·William H WarrenPaolo Gattuso
Sep 16, 2003·Cancer·Silvia PizziCesare Bordi
Mar 14, 2003·The Journal of Pathology·Davide SoldiniLuca Mazzucchelli
Dec 4, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiziana D'AddaCesare Bordi
Jun 15, 2007·Cancer·Antongiulio FaggianoEric Baudin
Jul 15, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TangjitgamolM T Deavers
Apr 5, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Daniel GonzalezLiron Pantanowitz
Mar 8, 2018·International Journal of Molecular Medicine·Yan YangWenzhe Li
Sep 15, 2012·Experimental and Therapeutic Medicine·Greta AlìGabriella Fontanini
Mar 21, 2020·Surgery Today·Akira IyodaAtsushi Sano
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Lamiaa ZidanRodney J Hicks
Nov 11, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·B C M HermansA-M C Dingemans
Jul 9, 2008·Archives of Pathology & Laboratory Medicine·Teri J Franks, Jeffrey R Galvin
Oct 12, 2021·Frontiers in Oncology·Yanan WangBaohui Han