Quantitative feed restriction rather than caloric restriction modulates the immune response of growing rabbits

The Journal of Nutrition
Christelle KnudsenI P Oswald

Abstract

Short-term feed restriction strategies are used in rabbits to reduce postweaning digestive disorders, but little is known about the involvement of the immune system in these beneficial effects. In the present study, the consequences of feed and energy restriction on immune response were investigated. At weaning, 320 male and female rabbits were assigned to 4 groups differing in dietary digestible energy (DE) concentrations and intake levels: a low-energy ad libitum-feed (LE100) group, a low-energy restricted-feed (LE75) group, a high-energy ad libitum-feed (HE100) group, and a high-energy restricted-feed (HE75) group. The high-energy groups consumed 10.13 MJ DE/kg of feed, whereas the low-energy groups consumed 9.08 MJ DE/kg (formulated values). Intake amounts for the restricted groups were 75% those of the ad libitum groups. Rabbits consumed these diets until age 63 d, after which they consumed feed ad libitum for 9 d. Ten rabbits per group and per age were killed at ages 42, 50, 63, and 72 d. Spleens and appendixes were weighed; Peyer's patch surface area was determined by image analysis; plasma total immunoglobulin (Ig) G and anti-ovalbumin IgG; and fecal and plasma IgA concentrations were determined by ELISA; and ileal expr...Continue Reading

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