Quantitative FT-Raman analysis of two crystal forms of a pharmaceutical compound

Journal of Pharmaceutical and Biomedical Analysis
F W LangkildeJ Mrak

Abstract

A pharmaceutical active compound H appears in two polymorphs, A and B, that are stable below and above room temperature, respectively. The A- and B-forms were found to have distinct FT-Raman spectra, in particular for a band at 1716 cm-1 (A-form) or 1724 cm-1 (B-form). Mixtures of A- in B-form were prepared, and the relative intensity of the characteristic bands at 1716 and 1724 cm-1 was found to be proportional to the relative amounts of A- and B-form in the mixtures. A calibration was made which was linear in the range from 1.8 to 15.4% (w/w) of A- in B-form. The results were compared with other methods for analysis of polymorphs: FT-IR spectrometry, differential scanning calorimetry, and powder X-ray diffractometry. A novel FT-Raman sample presentation method for inhomogeneous samples is presented.

References

Nov 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·H G BrittainA T Serajuddin

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Citations

Jun 14, 2005·Journal of Pharmaceutical and Biomedical Analysis·Jonas JohanssonStaffan Folestad
Apr 28, 2001·Advanced Drug Delivery Reviews·S R VippaguntaD J Grant
Apr 28, 2001·Advanced Drug Delivery Reviews·G A StephensonS M Reutzel-Edens
Apr 28, 2001·Advanced Drug Delivery Reviews·D E Bugay
Jun 7, 2002·Journal of Pharmaceutical and Biomedical Analysis·Sarra N Campbell RobertsSteven W Booth
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·N Al-ZoubiS Malamataris
Nov 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Jonas JohanssonLynne S Taylor
Mar 21, 1998·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A T De PaepeF W Langkilde
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Sep 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco Farias, Renato Carneiro
May 2, 2008·Journal of Pharmaceutical Sciences·Alan D GiftLynne S Taylor
Mar 1, 2005·Journal of Pharmaceutical Sciences·Nancy Redman-FureyDana Vaughn
Mar 29, 2005·Journal of Pharmaceutical Sciences·Takehiro Okumura, Makoto Otsuka
Apr 24, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Line Hagner NielsenAnette Müllertz
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Feb 3, 2007·The Journal of Pharmacy and Pharmacology·Jukka Rantanen
Feb 3, 2007·The Journal of Pharmacy and Pharmacology·Clare J StrachanJukka Rantanen
Apr 15, 2004·International Journal of Pharmaceutics·Adrian C WilliamsSteven W Booth
Jan 13, 2017·Bioscience, Biotechnology, and Biochemistry·Thao M HoBhesh R Bhandari
Nov 13, 2003·Applied Spectroscopy·M J Pelletier
Nov 22, 2007·Applied Spectroscopy·Jonas JohanssonMike Claybourn
Jun 4, 2015·Applied Spectroscopy·Hui WangReinhard Vehring
Jan 26, 2018·Pharmaceutics·Anna KaragianniKyriakos Kachrimanis
Nov 13, 2019·Angewandte Chemie·Christoffer K AbrahamssonGeorge M Whitesides
May 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Pentti NiemeläKristiina Järvinen
May 13, 2010·Molecular Pharmaceutics·Kristyn Greco, Robin Bogner

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