Quantitative gene expression of somatostatin receptors and noradrenaline transporter underlying scintigraphic results in patients with neuroendocrine tumors

Neuroendocrinology
Tina BinderupAndreas Kjaer

Abstract

To measure, by a quantitative approach, the gene expression underlying the results of somatostatin receptor (sst) scintigraphy ((111)In-DTPA-octreotide) and noradrenaline transporter (NAT) scintigraphy ((123)I-MIBG) in patients with neuroendocrine (NE) tumors. The gene expression of somatostatin receptors 1-5 (sst) and NAT was measured quantitatively by real-time PCR in a group of patients with NE tumors (n = 14) and compared to a group of patients with colorectal adenocarcinomas (n = 15). If available, scintigraphic results were compared with gene expression results (9 octreotide and 3 MIBG scintigraphies). The sst(2) was upregulated in 13 of 14 patients (93%) with NE tumors, and the absolute level of gene expression was highest for sst(2). Gene expression alterations of NAT and the other sst subtypes were more variable. Gene expression of sst(2) was in all cases in agreement with positive octreotide scintigraphies. In 2 of 3 cases where MIBG scintigraphy was positive, NAT was also upregulated. Sst(2) was generally downregulated in the colorectal tumor group with the gene expression of the other receptors being more heterogeneous. In general, changes in gene expression of sst(2) corresponded with scintigraphic results. Our dat...Continue Reading

References

Apr 1, 1984·Annals of Internal Medicine·C G MoertelA J Schutt
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H N LodeJ Beck
Jan 1, 1995·Life Sciences·Y C PatelC B Srikant
Aug 1, 1997·European Journal of Clinical Investigation·P JaïsM J Lewin
Jul 10, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SolciaR Fiocca
Nov 7, 1999·European Journal of Nuclear Medicine·A OtteJ Muller
Mar 16, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M PapottiG Bussolati
Nov 17, 2001·Virchows Archiv : an International Journal of Pathology·S ShibataM Nagata
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Michael HöpfnerHans Scherübl
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Jochen MundschenkHendrik Lehnert
Dec 24, 2003·Acta Oncologica·Isac I SchnirerJaffer A Ajani
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
Apr 15, 2006·Acta Radiologica·E D RappeportU Knigge
Nov 15, 2006·Annals of the New York Academy of Sciences·Lars KölbyHåkan Ahlman

❮ Previous
Next ❯

Citations

Feb 9, 2016·Diagnostics·Emma Elizabeth IlettUlrich Knigge
Aug 1, 2015·Acta Oncologica·Elizaveta Mitkina TabaksblatMorten Ladekarl
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anncatrine L PetersenThomas L Andresen
Dec 10, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Anncatrine Luisa PetersenThomas Lars Andresen
May 12, 2015·Scandinavian Journal of Gastroenterology·Andreas Kjaer, Ulrich Knigge
May 27, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Murat Fani BozkurtStefano Fanti
Apr 28, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Wolfgang RollKambiz Rahbar
Jul 12, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas PfeiferAndreas Kjaer
Sep 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Camilla B JohnbeckAndreas Kjaer
May 9, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas PfeiferAndreas Kjaer
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tina BinderupAndreas Kjaer
Oct 18, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tina BinderupAndreas Kjaer
Sep 25, 2018·Neuroendocrinology·Eric BaudinUNKNOWN ENETS 2016 Munich Advisory Board Participants
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.