Sep 17, 2015

Quantitative Genetics of Food Intake in Drosophila melanogaster

PloS One
Megan E GarlapowTrudy F C Mackay

Abstract

Food intake is an essential animal activity, regulated by neural circuits that motivate food localization, evaluate nutritional content and acceptance or rejection responses through the gustatory system, and regulate neuroendocrine feedback loops that maintain energy homeostasis. Excess food consumption in people is associated with obesity and metabolic and cardiovascular disorders. However, little is known about the genetic basis of natural variation in food consumption. To gain insights in evolutionarily conserved genetic principles that regulate food intake, we took advantage of a model system, Drosophila melanogaster, in which food intake, environmental conditions and genetic background can be controlled precisely. We quantified variation in food intake among 182 inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). We found significant genetic variation in the mean and within-line environmental variance of food consumption and observed sexual dimorphism and genetic variation in sexual dimorphism for both food intake traits (mean and variance). We performed genome wide association (GWA) analyses for mean food intake and environmental variance of food intake (using the coefficient of environm...Continue Reading

  • References190
  • Citations21

References

Mentioned in this Paper

Gzmb
Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Gene Polymorphism
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
EGFR
Biochemical Pathway
Immune System
Alg1

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