PMID: 9548555Apr 21, 1998Paper

Quantitative Golgi study of the rat cerebellar molecular layer interneurons using principal component analysis

The Journal of Comparative Neurology
F Sultan, J M Bower

Abstract

In this study, we applied for the first time a multivariate analysis to describe the anatomy of cerebellar molecular layer interneurons. Forty variables extending over a variety of morphological features (geometrical, topological, and metrical) were obtained from a three-dimensional reconstruction of 26 rat rapid Golgi-stained neurons. The subsequent principal component analysis showed that the first principal component was strongly correlated with variables related to the depth of each cell's soma in the molecular layer. The second principal component was strongly correlated with parameters describing axonal morphology. Finally, an analysis of the distribution of these anatomical features suggested that these cells cannot be classified into distinct groups but, instead, represent one continuously varying population. Thus, the classical division of molecular layer neurons into deep basket cells and superficial stellate cells is not supported by our analysis. These results have important implications for the development of the cerebellar cortex as well as for the expected patterns of Purkinje cell activity following activation of the granule cell layer.

Citations

May 21, 2004·Journal of Neurophysiology·Movses H Karakossian, Thomas S Otis
Feb 13, 2003·Annals of the New York Academy of Sciences·James M Bower
Sep 28, 2010·Trends in Neurosciences·Henrik JörntellChris I De Zeeuw
Nov 25, 2014·The Cerebellum·Henrik Jörntell
Jun 22, 2007·Brain Research Reviews·Mihail Bota, Larry W Swanson
Dec 23, 2004·The Journal of Physiology·Wolfgang MittmannMichael Häusser
Mar 24, 2006·The European Journal of Neuroscience·Sergio M G SolinasErik De Schutter
Dec 10, 2008·The Journal of Comparative Neurology·Chia-Chien ChenJoshua C Brumberg
Mar 16, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Craig D ByronVirginia Young
Jun 7, 2014·The European Journal of Neuroscience·Xiaohong SongMasahiko Watanabe
Dec 26, 2012·Neural Networks : the Official Journal of the International Neural Network Society·Fredrik BengtssonHenrik Jörntell
Feb 25, 2014·Neuron·Sarah RieublandMichael Häusser
May 4, 2010·Neuron·Federico F TrigoAlain Marty
Dec 19, 2014·Frontiers in Computational Neuroscience·William LennonTadashi Yamazaki
Jun 19, 2016·Journal of Theoretical Biology·Ivan Grbatinić, Nebojša Milošević
Jun 5, 2013·The European Journal of Neuroscience·Reinoud Maex, Volker Steuber
Mar 21, 2009·Journal of Neuroscience Research·Elizabeth R WhitneyGene J Blatt

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