Quantitative Hepatic Fat Quantification in Non-alcoholic Fatty Liver Disease Using Ultrasound-Based Techniques: A Review of Literature and Their Diagnostic Performance

Ultrasound in Medicine & Biology
Arinc OzturkManish Dhyani

Abstract

Non-alcoholic fatty liver disease is a condition that is characterized by the presence of >5% fat in the liver and affects more than one billion people worldwide. If adequate and early precautions are not taken, non-alcoholic fatty liver disease can progress to cirrhosis and death. The current reference standard for detecting hepatic steatosis is a liver biopsy. However, because of the potential morbidity associated with liver biopsies, non-invasive imaging biomarkers have been extensively investigated. Magnetic resonance imaging-based methods have proven accuracy in quantifying liver steatosis; however, these techniques are costly and have limited availability. Ultrasound-based quantitative imaging techniques are increasingly utilized because of their widespread availability, ease of use and relative cost-effectiveness. Several ultrasound-based liver fat quantification techniques have been investigated, including techniques that measure changes in the acoustic properties of the liver caused by the presence of fat. In this review, we focus on quantitative ultrasound approaches and their diagnostic performance in the realm of non-alcoholic fatty liver disease.

References

Aug 1, 1978·The Journal of the Acoustical Society of America·S A GossF Dunn
Mar 1, 1979·The British Journal of Radiology·A E JosephP G McGuire
Jan 1, 1979·Ultrasound in Medicine & Biology·J C Bamber, C R Hill
Sep 1, 1992·Medical Physics·E J BooteE L Madsen
Jan 1, 1991·Ultrasound in Medicine & Biology·D E RobinsonC F Chen
Jan 1, 1989·Ultrasound in Medicine & Biology·T A TuthillK J Parker
Nov 1, 1989·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·C C KuniD C Snover
May 1, 1989·The Journal of the Acoustical Society of America·L NockS W Smith
Jan 1, 1988·Ultrasound in Medicine & Biology·K J ParkerR C Waag
Mar 1, 1988·The Journal of the Acoustical Society of America·W D O'BrienT B Hebner
Apr 1, 1984·Ultrasonic Imaging·N F MakladV Balsara
Jan 1, 1981·Ultrasound in Medicine & Biology·J C BamberJ A King
Oct 1, 1993·Ultrasonic Imaging·J A ZagzebskiL X Yao
Aug 1, 1996·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·T MatsuhashiT Takahashi
Jul 1, 1997·Journal of Hepatology·C RicciL Dalla Palma
Nov 26, 1999·Ultrasound in Medicine & Biology·Z F LuF T Lee
Jun 30, 2000·The Journal of the Acoustical Society of America·M E AndersonG E Trahey
Jul 9, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yasutomo FujiiTakashi Itoh
Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Dec 8, 2004·Ultrasound in Medicine & Biology·Diana GaitiniHaim Azhari
Jan 27, 2005·AJR. American Journal of Roentgenology·Nancy A Obuchowski
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Apr 15, 2006·International Journal of Medical Sciences·Eugene J Yoon, Ke-Qin Hu
Oct 24, 2006·Ultrasonics·David NapolitanoRobert Steins
Jan 18, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·G Targher
Nov 22, 2007·AJR. American Journal of Roentgenology·Simon StraussLudmila Katsnelson
Feb 29, 2008·Journal of Hepatology·Nimantha Mark Wilfred de Alwis, Christopher Paul Day
Jul 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Johan M ThijssenChris L De Korte
Oct 23, 2009·Journal of Hepatology·Srinivasan DasarathyArthur J McCullough
Apr 12, 2011·The Journal of the Acoustical Society of America·Yassin Labyed, Timothy A Bigelow
Sep 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Scott B ReederClaude B Sirlin
Dec 20, 2011·Ultrasound in Medicine & Biology·Christopher T BarryKevin J Parker
Mar 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thuy-Anh LeUNKNOWN San Diego Integrated NAFLD Research Consortium (SINC)
Mar 23, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Robert P MyersMagdy Elkashab

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Citations

Mar 2, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhen HuangYan-Zhou Zhang
May 21, 2019·Expert Review of Gastroenterology & Hepatology·Stefano BallestriGiampiero Francica
Aug 30, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Haesung YoonMi Jung Lee
Jun 20, 2020·Journal of Clinical Gastroenterology·Maryam GhadimiIhab R Kamel
Oct 8, 2020·Abdominal Radiology·Jitka Starekova, Scott B Reeder
Sep 13, 2020·Ultrasound in Medicine & Biology·Jihye BaekKevin J Parker
Dec 22, 2020·Physics in Medicine and Biology·S S Poul, K J Parker
Apr 4, 2021·Journal of Clinical Medicine·Po-Ke HsuWei-Wen Su
Apr 20, 2021·Clinical Liver Disease·Suraj D SeraiSudha A Anupindi
Apr 29, 2021·Tissue Engineering. Part C, Methods·Yohei KumabeTakahiro Niikura
Jun 17, 2021·Seminars in Ultrasound, CT, and MR·Mayur VirarkarPriya Bhosale
Jun 23, 2021·Clinical and Molecular Hepatology·Seong Hee KangUNKNOWN Korean Association for the Study of the Liver (KASL)
Jul 29, 2021·Ultrasound in Medicine & Biology·Jihye BaekKevin J Parker
Sep 22, 2021·Radiology·Jitka StarekovaScott B Reeder

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