Quantitative high-performance liquid chromatographic assay for the determination of maprotiline and oxaprotiline in human plasma

Journal of Chromatography
H J Kuss, E Feistenauer

Abstract

A procedure is described which permits the determination of maprotiline and oxaprotiline in human blood or plasma at therapeutic concentrations. The biological fluids are extracted with base and the extract is injected into a high-performance liquid chromatograph. The substances are detected by a UV detector operating at 214 nm, amitriptyline being used as internal standard. Concentrations as low as 2 ng per sample can be measured.

References

Oct 1, 1979·Biomedical Mass Spectrometry·D AlkalayM F Bartlett
Dec 15, 1977·European Journal of Pharmacology·P C WaldmeierL Maître
Jul 1, 1977·Journal of Chromatography·J N ConnorH M Solomon
Nov 12, 1975·Journal of Chromatography·U P GeigerW Riess

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Citations

Jun 3, 1994·Journal of Chromatography. B, Biomedical Applications·H J KussD Y Zhao
Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·M JedrychowskiP R Bieck
Mar 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KasperH J Möller
Aug 4, 1997·Forensic Science International : Synergy·T Keller, U Zollinger
May 10, 1985·Journal of Chromatography·T R Norman, K P Maguire

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