Quantitative histochemical analysis of mast cells and sensory nerves in psoriatic skin

The Journal of Pathology
A NaukkarinenM Horsmanheimo

Abstract

To study the elements of neurogenic inflammation in psoriatic skin, morphological contacts were examined between mast cells and sensory nerves containing the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP) or vasoactive intestinal polypeptide (VIP). Because mast cells in psoriatic lesions appear in great numbers at the basement membrane (BM) zone, neuropeptide-mast cell contacts with the BM were also counted. A double stain for active mast cell tryptase and the neuropeptides was applied and the contacts were quantitated morphometrically. Sensory nerve-mast cell contacts were also studied three-dimensionally with a confocal laser scanning microscope. Increases in the contact values of SP and CGRP with mast cells, as well as with the BM, were obtained in developing (1-3 weeks) lesions when compared with their non-lesional controls. This increase reached statistical significance in mature lesions. In contrast, the corresponding contact values for VIP were decreased. By confocal microscopy, a close association between mast cells and sensory nerves was observed in the lesional dermis. Since tryptase is known to degrade CGRP but not SP, neurogenic stimuli, mainly via SP, can result in degranulation of mast cell...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Jan 1, 1992·Annals of the New York Academy of Sciences·K A Sharkey
Dec 1, 1992·Journal of Cellular Biochemistry·J LohiJ Keski-Oja
Jan 1, 1990·Archives of Biochemistry and Biophysics·S C AlterL B Schwartz
Jul 1, 1990·American Journal of Respiratory Cell and Molecular Biology·E K Tam, G H Caughey
Jan 1, 1990·Archives of Dermatological Research·I T HarvimaM Horsmanheimo
Jul 1, 1990·International Journal of Dermatology·A S Boyd, K H Neldner
Jan 1, 1987·International Archives of Allergy and Applied Immunology·J BienenstockJ A Denburg
Jan 1, 1987·International Archives of Allergy and Applied Immunology·J C Foreman
Jan 1, 1989·The Journal of Investigative Dermatology·A NaukkarinenE M Farber
Jan 1, 1989·Archives of Dermatological Research·I T HarvimaM Horsmanheimo
Jan 1, 1984·Histochemistry·C J DalsgaardD Dahl
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology·C PincelliA Giannetti
Jun 1, 1993·The British Journal of Dermatology·D J Eedy
Jan 1, 1993·Archives of Dermatological Research·I T HarvimaM Horsmanheimo
Apr 1, 1993·Journal of the Neurological Sciences·W R Kennedy, G Wendelschafer-Crabb

❮ Previous
Next ❯

Citations

Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Theoharis C TheoharidesPio Conti
Oct 16, 2014·European Journal of Immunology·Mariona Baliu-PiquéBernhard Holzmann
Nov 18, 2011·The Journal of Investigative Dermatology·Shahrzad AsadiTheoharis C Theoharides
Dec 17, 2008·Brain, Behavior, and Immunity·Frank J SymonsJames W Bodfish
Sep 27, 2003·The British Journal of Dermatology·G YosipovitchC L Goh
Nov 6, 2009·Experimental Dermatology·Ricardo Filipe da Silva CarvalhoIlkka Tapani Harvima
Jun 20, 2015·Nature Reviews. Neuroscience·Stephen B McMahonDavid L H Bennett
Dec 28, 2010·Biochimica Et Biophysica Acta·Theoharis C TheoharidesDimitrios Kalogeromitros
May 22, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y YuW Jiang
Jun 25, 2016·Reviews in Endocrine & Metabolic Disorders·Theoharis C TheoharidesChristos C Zouboulis
Nov 15, 2016·The Ocular Surface·Francesco SabatinoStefano Bonini
Mar 20, 1999·The Journal of Investigative Dermatology·A RoweC B Bunker
Jan 18, 2017·Experimental Dermatology·Theoharis C Theoharides
Apr 11, 2018·The FEBS Journal·Landon K Oetjen, Brian S Kim
Mar 21, 2007·Archives of Dermatological Research·Charlotta RemrödKlas Nordlind
Aug 23, 2008·Archives of Dermatological Research·Ilkka T HarvimaAnita Naukkarinen
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Nov 25, 2011·Amino Acids·Bernhard Holzmann
Apr 28, 2011·Experimental Dermatology·Julia RadosaHjalmar Kurzen
Mar 7, 2012·Expert Review of Clinical Immunology·Ilkka T Harvima, Gunnar Nilsson
Jul 26, 2019·Experimental Dermatology·Franz J Legat
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wondossen SimeManuel Patarroyo
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marit D HarzenetterBernhard Holzmann
Oct 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min-Hee OhTao Zheng
Mar 13, 2003·Experimental Dermatology·Petri K KivinenIlkka T Harvima
Apr 24, 2003·Archives of Dermatological Research·Anitta JärvikallioAnita Naukkarinen
Feb 13, 2018·Immunological Reviews·Kalpna Gupta, Ilkka T Harvima
Jan 7, 2020·Neuropeptides·Ana Karen Sandoval-TalamantesAnabell Alvarado-Navarro
Mar 26, 2019·International Archives of Allergy and Immunology·Kyung-Ah ChoSo-Youn Woo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.