PMID: 7292976Jan 1, 1981Paper

Quantitative histological and immunohistochemical findings in jejunal biopsy specimens in giardiasis

Virchows Archiv. A, Pathological Anatomy and Histology
P C RosekransC J Meijer

Abstract

Jejunal mucosa biopsies from non-immune deficient patients with Giardia lamblia infestation were examined and showed three different groups of mucosal changes, distinguishable on morphological and immunohistochemical grounds. In three patients no morphological or immunohistochemical abnormalities were found (group A). In five patients a normal villous architecture was seen. These biopsies had increased numbers of interepithelial lymphocytes and of immunoglobulin containing cells in the lamina propria, with a relative increase of the number of IgA and IgG containing cells (group B). Two patients with a malabsorption syndrome due to giardiasis had marked villous atrophy, documented by morphometric measurements and large numbers of interepithelial lymphocytes and of immunoglobulin containing cells in the lamina propria, especially IgA and IgG (group C). These findings differ considerably from those in patients with immunodeficiency or gluten sensitive enteropathy. This suggests that when villous atrophy of the jejunal mucosa is found immunohistochemistry of jejunal biopsy specimens may be helpful in the differential diagnosis between mere giardiasis and giardiasis superimposed on immunodeficiency or gluten sensitive enteropathy.

References

May 6, 1978·Lancet·W K BlenkinsoppG P Haffenden
Aug 1, 1978·Journal of Clinical Pathology·S G Wright, A M Tomkins
Sep 1, 1976·Acta paediatrica Scandinavica·A FergusonR R Townley
Jan 1, 1976·Journal of Clinical Pathology·M J Ridley, D S Ridley
Sep 1, 1974·The American Journal of Digestive Diseases·E G Jones, W R Brown

Citations

Jul 1, 1993·Gastroenterology·A M CevallosM J Farthing
Jul 1, 1987·Baillière's Clinical Gastroenterology·M J Farthing, A K Goka
Jan 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·M J Farthing
Aug 1, 1990·Journal of Clinical Pathology·G Oberhuber, M Stolte
Sep 1, 1995·Gastroenterology·A M CevallosJ G Farthing
Sep 1, 1995·Scandinavian Journal of Gastroenterology·G Oberhuber, M Stolte
Dec 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J Farthing

Related Concepts

Atrophic
Biopsy
Giardiasis
IgA2
Polyglobin
Structure of Intestinal Gland
Jejunum

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