Quantitative Histomorphometry of the Healthy Peritoneum

Scientific Reports
Betti SchaeferClaus P Schmitt

Abstract

The peritoneum plays an essential role in preventing abdominal frictions and adhesions and can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal and 69 omental specimens were obtained from 107 patients (0.1-60 years) undergoing surgery for disease not affecting the peritoneum for automated quantitative histomorphometry and immunohistochemistry. The mesothelial cell layer morphology and protein expression pattern is similar across all age groups. Infants below one year have a thinner submesothelium; inflammation, profibrotic activity and mesothelial cell translocation is largely absent in all age groups. Peritoneal blood capillaries, lymphatics and nerve fibers locate in three distinct submesothelial layers. Blood vessel density and endothelial surface area follow a U-shaped curve with highest values in infants below one year and lowest values in children aged 7-12 years. Lymphatic vessel density is much lower, and again highest in infants. Omental blood capillary density correlates with parietal peritoneal findings, whereas only few lymphatic vessels are present. The healthy peritoneum exhibits major thus far unknown particularitie...Continue Reading

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Citations

Apr 20, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michel FischbachClaus Peter Schmitt
Oct 11, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Claus Peter Schmitt, Christoph Aufricht
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Jul 25, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alferso C AbrahamsTri Q Nguyen
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Feb 1, 2019·Frontiers in Physiology·Maria Bartosova, Claus Peter Schmitt
Jul 16, 2019·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Marco A BrunoFernando A Alvarez
Jul 15, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alena ParikovaRaymond T Krediet
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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT01893710

Software Mentioned

Aperio Image Analysis
Image Scope
Aperio

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