PMID: 8600795Aug 1, 1995Paper

Quantitative image analysis of p53 protein accumulation in keratoacanthomas

The American Journal of Dermatopathology
A BorkowskiB F Trump

Abstract

Keratoacanthomas are benign skin tumors that grow rapidly but eventually regress. They occur most commonly in sun-exposed skin and are histologically remarkably similar to squamous cancers. Since mutations of the p53 tumor suppressor gene are found frequently in cutaneous squamous cell carcinomas, we hypothesized that p53 mutations might contribute to the development of keratoacanthomas. To address this question, we did p53 immunohistochemistry with a polyclonal rabbit antiserum, CM-1, that binds both mutant and wild-type p53 proteins. Although wild-type p53 protein degrades rapidly and is generally undetected by immunohistochemistry, mutant p53 protein has a longer half-life and accumulates to detectable levels. We tested 26 formalin-fixed keratoacanthomas and 4 normal skin biopsies. Positive nuclear staining was detected in 20 of 26 (77%) of the keratoacanthomas and in none of the normal skin samples. Nuclear staining occurred in the outermost layer of the neoplasms and not in the keratin-filled central cores. Since nuclear p53 protein within a cutaneous squamous cell carcinoma usually correlates with missense mutation, these data suggest that p53 mutations contribute to the development of this benign neoplasm. The histologic...Continue Reading

Citations

Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
Apr 16, 2005·Journal of Korean Medical Science·Tae-Won HaDae-Kwang Kim
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
Oct 16, 2019·Indian Journal of Pathology & Microbiology·Gulay TuranOzgur Kulahci
Dec 21, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jens J ThielePeter Elsner
Mar 30, 2016·Journal of Cutaneous Pathology·Sarita JoshiOle Petter F Clausen

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