Quantitative imaging in breast tomosynthesis and CT: comparison of detection and estimation task performance

Medical Physics
Samuel Richard, Ehsan Samei

Abstract

This work investigates a framework for modeling volumetric breast imaging to compare detection and estimation task performance and optimize quantitative breast imaging. Volumetric reconstructions of a breast phantom, which incorporated electronic, quantum, and anatomical noise with embedded spherical lesions, were simulated over a range of acquisition angles varying from 4 degrees to 204 degrees with a constant total acquisition dose of 1.5 mGy. A maximum likelihood estimator was derived in terms of the noise power spectrum, which yielded figures of merit for quantitative imaging performance in terms of accuracy and precision. These metrics were computed for estimation of lesion area, volume, and location. Estimation task performance was optimized as a function of acquisition angle and compared to the performance of a more conventional lesion detection task. Results revealed tradeoffs between electronic, quantum, and anatomical noise. The detection of a 4 mm sphere was optimal at an acquisition angle of 84 degrees, where reconstructed images using a smaller acquisition angle exhibited increased anatomical noise and reconstructed images using a larger acquisition angle exhibited increased quantum and electronic noise. For all es...Continue Reading

References

Jul 1, 1990·Journal of the Optical Society of America. A, Optics and Image Science·H H Barrett
Jun 1, 1987·Physics in Medicine and Biology·P C Johns, M J Yaffe
May 1, 1987·Journal of the Optical Society of America. A, Optics and Image Science·M RabbaniR Van Metter
May 1, 1995·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·H H BarrettK J Myers
Sep 18, 1997·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·A E BurgessC K Abbey
May 8, 2001·Medical Physics·A E BurgessP F Judy
Dec 6, 2003·Medical Physics·Robert S Saunders, Ehsan Samei
Aug 4, 2005·Physics in Medicine and Biology·Stefan P MüllerMarie Foley Kijewski
Jun 22, 2006·Future Oncology·John M Boone, Karen K Lindfors
Sep 21, 2006·Physics in Medicine and Biology·C N BrzymialkiewiczJ E Bowsher
Jan 24, 2007·Academic Radiology·Sara C ChenAndrew D A Maidment
Feb 7, 2007·Medical Physics·S Richard, J H Siewerdsen
Jul 25, 2007·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Randolph L McKinleyJames E Bowsher
Apr 4, 2008·Medical Physics·Samuel Richard, Jeffrey H Siewerdsen
May 22, 2008·Medical Physics·Amarpreet S ChawlaJay A Baker
Jul 22, 2008·Radiology·Daniel C Sullivan
Nov 4, 2008·Medical Physics·Kathrine G MetheanyJohn M Boone
Jan 30, 2009·Medical Physics·Daniel J Tward, Jeffrey H Siewerdsen
Jun 24, 2009·Medical Physics·Emma EngstromRobert Nishikawa
Jun 1, 2006·Journal of the ICRU·André Wambersie

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Citations

Aug 4, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Frédéric A MiévilleFrançois R Verdun
Oct 14, 2011·Medical Physics·I ReiserR M Nishikawa
Feb 10, 2011·Medical Physics·Samuel Richard, Ehsan Samei
Sep 7, 2011·Academic Radiology·Jay A Baker, Joseph Y Lo
Nov 17, 2015·IEEE Transactions on Medical Imaging·Changwoo Lee, Jongduk Baek
Jan 26, 2017·Medical Physics·Yakun ZhangEhsan Samei
May 18, 2018·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Ehsan SameiJenia Vassileva
Feb 6, 2020·Medical Physics·Gihun KimJongduk Baek
Jul 22, 2011·Physics in Medicine and Biology·Ehsan SameiCarl E Ravin
Jun 22, 2013·Physics in Medicine and Biology·Yulia M LevakhinaThorsten M Buzug
Feb 21, 2013·Physics in Medicine and Biology·E SameiS Richard
Jan 22, 2019·Journal of Medical Imaging·Sean D RoseXiaochuan Pan
Aug 14, 2013·Physics in Medicine and Biology·I ReiserR M Nishikawa

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