Quantitative Imaging in Cancer Clinical Trials.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Thomas E YankeelovDaniel L Rubin

Abstract

As anticancer therapies designed to target specific molecular pathways have been developed, it has become critical to develop methods to assess the response induced by such agents. Although traditional, anatomic CT, and MRI examinations are useful in many settings, increasing evidence suggests that these methods cannot answer the fundamental biologic and physiologic questions essential for assessment and, eventually, prediction of treatment response in the clinical trial setting, especially in the critical period soon after treatment is initiated. To optimally apply advances in quantitative imaging methods to trials of targeted cancer therapy, new infrastructure improvements are needed that incorporate these emerging techniques into the settings where they are most likely to have impact. In this review, we first elucidate the needs for therapeutic response assessment in the era of molecularly targeted therapy and describe how quantitative imaging can most effectively provide scientifically and clinically relevant data. We then describe the tools and methods required to apply quantitative imaging and provide concrete examples of work making these advances practically available for routine application in clinical trials. We concl...Continue Reading

References

Nov 11, 1998·Nature Medicine·A F ShieldsT J Mangner
Aug 10, 2000·Magnetic Resonance Imaging·A W AndersonJ C Gore
Jun 17, 2008·The Oncologist·Annick D Van den Abbeele
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hee-Jung SohnSang-We Kim
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Oct 16, 2009·Current Medical Imaging Reviews·Thomas E Yankeelov, John C Gore
Dec 3, 2009·Radiology·David S ChanninDaniel L Rubin
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Jun 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Binsheng ZhaoLawrence H Schwartz
Sep 14, 2010·Medical Physics·Frederic H FaheyTina Young Poussaint
Mar 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda MileshkinBernard M Fine
May 31, 2012·Journal of Digital Imaging·Bradley J EricksonUNKNOWN CTSA Imaging Informatics Project Group
Jun 9, 2012·Journal of Digital Imaging·Tony PanUNKNOWN CTSA Imaging Informatics Project Group
Jun 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajul K JainRazelle Kurzrock
Jun 15, 2012·Nature Reviews. Cancer·Robert J GilliesRobert A Gatenby
Oct 2, 2012·Journal of Magnetic Resonance Imaging : JMRI·Dariya MalyarenkoThomas L Chenevert
May 31, 2013·Science Translational Medicine·Thomas E YankeelovVito Quaranta
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hubert PiessevauxSabine Tejpar
Sep 26, 2013·Radiology·Robert A GatenbyRobert J Gillies
Nov 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oriana YuLaurent Azoulay
Dec 18, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·B E ZimmermanM M Mille
Mar 13, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David A MankoffAmy S Clark
Apr 29, 2014·Translational Oncology·Daniel L RubinDilvan A Moreira
Apr 29, 2014·Translational Oncology·Robert K DootPaul E Kinahan
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James M MountzRichard L Wahl

❮ Previous
Next ❯

Citations

Mar 30, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Aniek J G EvenWouter van Elmpt
Nov 3, 2016·Nature Reviews. Clinical Oncology·James P B O'ConnorJohn C Waterton
Mar 24, 2018·Journal of Magnetic Resonance Imaging : JMRI·Anna G SoraceJohn Virostko
Feb 1, 2018·Journal of Radiation Research·Jia WuRuijiang Li
Mar 3, 2018·Chemical Society Reviews·Pengcheng ZhangHonggang Cui
Jun 26, 2018·Journal of Surgical Oncology·David A Mankoff, Sharyn I Katz
Nov 28, 2018·Radiology·Ronald L Wolf
Feb 27, 2019·JCO Clinical Cancer Informatics·David A HormuthThomas E Yankeelov
Mar 30, 2019·Journal of Magnetic Resonance Imaging : JMRI·David A HormuthThomas E Yankeelov
May 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharyl J NassHedvig Hricak
Mar 4, 2020·Journal of Personalized Medicine·Enrico Capobianco, Marco Dominietto
Jun 2, 2020·JCO Clinical Cancer Informatics·Ashish SharmaFred Prior
Dec 6, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Katherine E HersbergerVaibhav Sahai
Apr 12, 2017·European Journal of Nuclear Medicine and Molecular Imaging·S LheureuxF M Mottaghy
May 7, 2020·Radiation Oncology·Christopher KurzMarco Riboldi
May 26, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Milan GrkovskiJohn L Humm
Jan 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jia WuRuijiang Li
Feb 18, 2021·AJR. American Journal of Roentgenology·Francesco AlessandrinoNikhil H Ramaiya
Apr 28, 2021·Clinical Radiology·H M C Cheung, D Rubin
Mar 16, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yoganand BalagurunathanIssam El Naqa
Jun 22, 2021·Nature Reviews. Neurology·Marion Smits
Jul 21, 2021·Abdominal Radiology·Paul Kennedy, Bachir Taouli
Jul 22, 2021·Computer Methods and Programs in Biomedicine·Maureen van EijnattenRamona Woitek
Nov 13, 2021·Journal of Magnetic Resonance Imaging : JMRI·Sean D McGarryPeter S LaViolette

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Joyce Liu, Ursula A Matulonis
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Juliane M JürgensmeierRoy S Herbst
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Janakiraman SubramanianRamaswamy Govindan
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Michail IgnatiadisStefanie S Jeffrey
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Gerold Bepler
© 2022 Meta ULC. All rights reserved