Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT

Scientific Reports
L PorraS Bayat

Abstract

To understand the determinants of inhaled aerosol particle distribution and targeting in the lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial. No single imaging modality allows the acquisition of all such data together. Here we assessed the feasibility of dual-energy synchrotron radiation imaging to this end in anesthetized rabbits; both in normal lung (n = 6) and following methacholine (MCH)-induced bronchoconstriction (n = 6), a model of asthma. We used K-edge subtraction CT (KES) imaging to quantitatively map the regional deposition of iodine-containing aerosol particles. Morphological and regional ventilation images were obtained, followed by quantitative regional iodine deposition maps, after 5 and 10 minutes of aerosol administration. Iodine deposition was markedly inhomogeneous both in normal lung and after induced bronchoconstrition. Deposition was significantly reduced in the MCH group at both time points, with a strong dependency on inspiratory flow in both conditions (R2 = 0.71; p < 0.0001). We demonstrate for the first time, the feasibility of KES CT for quantitative imaging of lung deposition of aerosol particles, regional ventilation and morphology. Since these are among...Continue Reading

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Citations

Jan 19, 2019·Journal of Synchrotron Radiation·Martin DonnelleyDavid W Parsons
Dec 24, 2019·Journal of Synchrotron Radiation·Kaye Susannah MorganMartin Donnelley
Jul 4, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·J AlbersC Dullin
Feb 20, 2021·Scientific Reports·Amara KhanChristian Dullin

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Methods Mentioned

BETA
imaging techniques
x-ray tomography
imaging technique
X-ray
fluorescence imaging

Software Mentioned

SigmaPlot
Systat
MATLAB

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