Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response

Carcinogenesis
R H DashwoodG S Bailey

Abstract

A number of recent studies have described inhibitor-mediated reductions in the covalent DNA binding and tumorigenicity of various carcinogens, in species such as rats, mice and rainbow trout (Salmo gairdneri). Since inhibitory effects have, in most cases, been reported after testing at one carcinogen and one inhibitor level only, the detailed relationships between carcinogen dose, inhibitor dose, in vivo DNA binding and final tumor response are not well understood in any species. To determine these relationships we have employed the trout model in a combined DNA binding/tumor dose-response protocol using approximately 10,000 animals. Trout were pretreated with one of five different dose-levels of indole-3-carbinol (I3C), a naturally occurring anti-carcinogen found in cruciferous vegetables such as broccoli and cabbage. After 4 weeks, animals received the same dietary level of I3C for a further 2 weeks together with [3H]aflatoxin B1 (AFB1) in the dose-range 10-320 p.p.b. From tanks containing 150 animals (three tanks per I3C-AFB1 dose-point), 15 fish were selected at random in order to assess hepatic AFB1-DNA binding levels. Remaining animals were returned to control diet for determination of tumor response at 12 months. Linear ...Continue Reading

Citations

Jun 1, 1992·Mutation Research·G BaileyR Dashwood
May 1, 1994·Mutation Research·L R Ferguson
Mar 17, 1995·Mechanisms of Ageing and Development·M Chelcheleh, A Allameh
Jun 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R H DashwoodG S Bailey
Nov 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S LoftH Sørensen
Feb 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N TakahashiD E Williams
Oct 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N TakahashiG S Bailey
Oct 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N TakahashiG S Bailey
May 5, 1998·Chemico-biological Interactions·R H Dashwood
Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R H Dashwood, M Xu
Feb 17, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E O FarombiG O Emerole
Apr 1, 1997·Critical Reviews in Oncology/hematology·T Tanaka
Dec 10, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Gary H ThorgaardYniv Palti
May 20, 2009·Chemical Research in Toxicology·George S BaileyJames A Swenberg
Mar 1, 1993·Environmental Health Perspectives·F A Beland, M C Poirier
Mar 1, 1993·Environmental Health Perspectives·J C HarrisonR C Garner
Mar 1, 1996·Environmental Health Perspectives·G S BaileyJ D Hendricks
Jun 1, 1997·Environmental Health Perspectives·G D StonerG J Kelloff
Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jay H Fowke
Sep 5, 2002·Environmental and Molecular Mutagenesis·M Vijayaraj ReddySheila M Galloway
Jun 8, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nagendra Kumar KaushikEun Ha Choi
Jan 1, 1994·Drug Metabolism Reviews·S Garattini
Jun 28, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·David E Williams
Feb 28, 1997·Chemico-biological Interactions·D T VerhoevenG van Poppel
Nov 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tammie J McQuistanGeorge S Bailey
Aug 1, 1989·Regulatory Toxicology and Pharmacology : RTP·D H Bechtel
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand
Sep 18, 2020·Antioxidants·Shamee Bhattacharjee, Roderick H Dashwood

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