Quantitative interpretation of PAMAM dendrimers adsorption on silica surface

Journal of Colloid and Interface Science
Karolina Tokarczyk, Barbara Jachimska

Abstract

Understanding the dendrimer-solid support interaction is of great importance for dendrimer-based drug delivery system design. The maximum surface coverage on a hydrophilic silica surface was determined using the quartz crystal microbalance with dissipation monitoring (QCM-D) and multi-parametric surface plasmon resonance (MP-SPR) methods: the adsorption process depends on ionic strength and pH of solutions. The effectiveness of G6 adsorption is mainly determined by the range of electrostatic inter-dendrimer interactions and dendrimer-silica surface interactions. Changes in ionic strength have a strong effect on the binding affinity of dendrimers to the surface. The trends in the binding affinity and the surface saturation amount correspond well with the degree of change of protonation of the adsorbed molecules. The development of new research techniques makes it possible to attain a more profound understanding of the self-assembling behaviour of dendrimers. The comparison of QCM-D and MP-SPR allowed the estimation that the dendrimer film contains approximately 70% water. These results indicate that 6th generation PAMAM dendrimers form very hydrated films on silica surfaces. In this case the number of water molecules associated ...Continue Reading

Citations

Feb 24, 2018·Soft Matter·Mounika Gosika, Prabal K Maiti
Jan 14, 2021·Nanomaterials·Anna Bratek-SkickiZbigniew Adamczyk
Jul 14, 2021·The Journal of Physical Chemistry. B·Aneta MichnaOzlem Ozcan
Aug 25, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Athénaïs DavantèsDenis Renard
Jul 6, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Mounika GosikaPrabal K Maiti
May 5, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Mounika GosikaPrabal K Maiti

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