Quantitative iodine-123-metaiodobenzylguanidine (MIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: Development and validation of automated procedures in conjunction with technetium-99m tetrofosmin myocardial perfusion SPECT

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Ian P ClementsArnold F Jacobson

Abstract

The purpose of this study was to develop and validate new approaches to quantitative MIBG myocardial SPECT imaging in heart failure (HF) subjects. Quantitative MIBG myocardial SPECT analysis methods, alone and in conjunction with 99mTc-tetrofosmin perfusion SPECT, were adapted from previously validated techniques for the analysis of SPECT and PET perfusion imaging. To account for underestimation of MIBG defect severity in subjects with global reduction in uptake, a mixed reference database based on planar heart/mediastinum (H/M) ratio categories was used. Extent and severity of voxel-based defects and number of myocardial segments with significant dysinnervation (derived score ≥2) were determined. MIBG/99mTc-tetrofosmin mismatch was quantified using regions with preserved innervation as the reference for scaling 99mTc-tetrofosmin voxel maps. Quantification techniques were tested on studies of 619 ischemic (I) and 319 non-ischemic (NI) HF subjects. Using all analytical techniques, IHF subjects had significantly greater and more severe MIBG SPECT abnormalities compared with NIHF subjects. Innervation/perfusion mismatches were also larger in IHF subjects. Findings were consistent between voxel- and myocardial-segment-based quantit...Continue Reading

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Citations

Mar 25, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I Travin
May 21, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberta Assante, Wanda Acampa
Nov 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Alessia GimelliMaria Grazia Bongiorni
Dec 29, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alessia GimelliPaolo Marzullo
Aug 16, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alessia GimelliPaolo Marzullo
Jan 14, 2017·Current Cardiology Reports·Mark I Travin
May 14, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hironori YamamotoMasatake Fukunami
Jul 3, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Riccardo LigaAnna Sonia Petronio
Apr 27, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Anna Teresińska
Nov 26, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marcelo José Dos SantosJosé Soares Junior
Sep 5, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I TravinKeiichiro Yoshinaga
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aukelien C Dimitriu-LeenArnold F Jacobson
Sep 17, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Raza AlviYi-Hwa Liu

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