Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk.

Frontiers in Nutrition
Xinhao ZhangFuwei Zhao

Abstract

Previous studies have found donkey milk (DM) has the similar compositions with human milk (HM) and could be used as a potential hypoallergenic replacement diet for babies suffering from cow's milk allergy. Milk fat globule membrane (MFGM) proteins are involved in many biological functions, behaving as important indicators of the nutritional quality of milk. In this study, we used label-free proteomics to quantify the differentially expressed MFGM proteins (DEP) between DM (in 4-5 months of lactation) and HM (in 6-8 months of lactation). In total, 293 DEP were found in these two groups. Gene Ontology (GO) enrichment analysis revealed that the majority of DEP participated in regulation of immune system process, membrane invagination and lymphocyte activation. Several significant Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined for the DEP, such as lysosome, galactose metabolism and peroxisome proliferator-activated receptor (PPAR) signaling pathway. Our study may provide valuable information in the composition of MFGM proteins in DM and HM, and expand our knowledge of different biological functions between DM and HM.

References

Jul 1, 1985·Archives of Disease in Childhood·P Juto
Jun 30, 2000·Neurological Research·J KalmanA G Lacko
Sep 6, 2000·Scandinavian Journal of Immunology·F E JohansenP Brandtzaeg
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A CarroccioG Iacono
Sep 6, 2001·The Journal of Experimental Medicine·L ErlandssonT Leanderson
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Renata R CoccoKirsten Beyer
Aug 19, 2003·Trends in Cardiovascular Medicine·Chieko Mineo, Philip W Shaul
Nov 19, 2003·Pflügers Archiv : European journal of physiology·Matthias A HedigerElspeth A Bruford
Jul 13, 2006·The Journal of Dairy Research·Timothy A Reinhardt, John D Lippolis
May 9, 2007·The Journal of Experimental Medicine·Hye-Ryun KangJack A Elias
Jan 18, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanna MontiAmedeo Conti
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Julien MuffatSeymour Benzer
Oct 29, 2009·Journal of Mass Spectrometry : JMS·Vincenzo CunsoloSalvatore Foti
Dec 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sylwia OwczarekVladislav Soroka
Dec 29, 2009·Frontiers in Bioscience (Elite Edition)·Enrico BertinoAmedeo Conti
Mar 25, 2011·Biochemical Society Transactions·Christopher G Proud
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Andreas J SteckSusanne Renaud
Sep 8, 2011·The Journal of Biological Chemistry·Marta Biedzka-SarekMatti Jauhiainen
Nov 16, 2011·Journal of the Science of Food and Agriculture·Elinor MedhammarBarbara Burlingame
Jan 26, 2013·Proteomics·Besma SaadaouiChristelle Cebo
Mar 6, 2013·Journal of Paediatrics and Child Health·Bo Lönnerdal
Oct 3, 2013·BMC Immunology·Stefan VordenbäumenMatthias Schneider
Nov 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Anne JensenCarsten Uhd Nielsen
Dec 5, 2013·Pathology·Joris R DelangheMarijn M Speeckaert
Dec 1, 2008·Trends in Food Science & Technology·Nurit ArgovJ Bruce German
Jan 15, 2014·The Journal of Nutritional Biochemistry·Yasuaki Wada, Bo Lönnerdal
Feb 26, 2016·Molecular Nutrition & Food Research·Stefan VordenbäumenMatthias Schneider
Feb 23, 2017·Paediatrics and International Child Health·Ponpan MatangkasombutWiparat Manuyakorn
Jun 21, 2017·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Seong-Min KimKyung-Hyun Cho
Aug 9, 2017·Food Research International·Vincenzo CunsoloSalvatore Foti
Oct 22, 2018·Pflügers Archiv : European journal of physiology·Joanne Marks
Jan 9, 2019·Frontiers in Cellular Neuroscience·Maryam Rahimi-BalaeiHassan Marzban
Mar 27, 2020·Frontiers in Immunology·Vijaya Iragavarapu-CharyuluAlexandra Urdaneta
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Chengliang HuLigong Chen
Oct 11, 2020·Journal of Proteomics·Valentina SpadaGianluca Picariello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.