Quantitative localization of biogenic amines in the spinal cord.

Brain Research
J A ZivinI J Kopin

Abstract

Recently developed highly sensitive radiometric assays for biogenic amines have been combined with microdissection techniques to localize and quantify these amines in different structures, and at various levels of rabbit and rat spinal cords. Assays were performed for serotonin, norepinephrine, dopamine and epinephrine. It was generally found that the highest concentrations of those biogenic amines were found in the lateral and ventral horns, slightly lesser concentrations were found around the central canal, and still lower concentrations were found in the dorsal horns. Relatively low amine concentrations were found in the white matter. These biochemical measurements correlate well with localizations indicated by histofluorescence methods but provide precise quantification. Comparisons with previously available, less sensitive biochemical measurements are discussed.

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Citations

Aug 15, 1977·Experientia·J Geber, M Dupelji
May 28, 1976·Brain Research·M G ZieglerI J Kopin
Jul 27, 1981·Brain Research·N S SharplessL I Wolfson
Jan 10, 1983·Brain Research·J A Zivin, D R Waud
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Jan 25, 2002·The Journal of Comparative Neurology·Ingela Hammar, David J Maxwell

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