Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors.

Experimental Biology and Medicine
Tanushree BoseA G Comuzzie

Abstract

gamma Glutamyl transferase (GGT) and albumin (ALB) are two markers of liver function. These two proteins have been associated with non-alcoholic fatty liver disease and cardiovascular disease. The objectives of this study were to explore the genetic factors that influence variation in the plasma levels of GGT and ALB and to evaluate their genetic correlations with cardiovascular risk factors. Baboons from the Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, were used as an animal model. The baboons were fed a standard monkey chow diet ad libitum. Fasting plasma concentrations of GGT, ALB, triglycerides, total cholesterol and LDL cholesterol were measured in 350 pedigreed adult baboons by standard assay procedures. A maximum likelihood-based variance decomposition approach implemented in the computer program SOLAR was used to conduct genetic analyses. The heritabilities of GGT (h(2) = 0.55; P < 0.0001) and ALB (h(2) = 0.42; P < 0.01) were significant. No statistically significant associations were found between GGT and the cardiovascular-related phenotypes. Genetic correlations between ALB and total cholesterol, LDL cholesterol and triglycerides were significant. A ...Continue Reading

References

Jan 1, 1995·Genetic Epidemiology·C M Lewis, D E Goldgar
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Aug 24, 1999·The Journal of Biological Chemistry·Q A SunV N Gladyshev
Jan 23, 2002·American Journal of Medical Genetics·K M KirkN G Martin
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Srinivasan BeddhuUNKNOWN HEMO Study Group
Jan 17, 2003·Obesity Research·Anthony G ComuzzieJohn L VandeBerg
Mar 11, 2004·American Journal of Physiology. Endocrinology and Metabolism·Uwe J F TietgeMatthias J Bahr
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiArthur J McCullough
May 29, 2004·Obesity Research·M Elizabeth TejeroAnthony G Comuzzie
Aug 25, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M E TejeroA G Comuzzie
Oct 8, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lise BathumKaare Christensen
Dec 17, 2004·Obesity Research·Guowen CaiAnthony G Comuzzie
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·L A Adams, P Angulo
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Jan 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Emilio OrtegaJoy C Bunt
Mar 17, 2006·Journal of Clinical Gastroenterology·Iris Liou, Kris V Kowdley
Sep 15, 2006·Atherosclerosis·Giovanni Targher, Guido Arcaro
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Oct 4, 2006·International Journal of Molecular Medicine·Iván PalomoJosep M Argilés
Oct 13, 2006·Atherosclerosis·Atsushi HozawaUNKNOWN NIPPON DATA90 Research Group
Nov 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Douglas S LeeRamachandran S Vasan
Jan 18, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·G Targher
Sep 27, 2007·European Heart Journal·Nisha I ParikhRamachandran S Vasan
Nov 28, 2007·Clinical Chemistry·Alexander StrasakUNKNOWN VHM&PP Study Group
Jul 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander M StrasakUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Dec 18, 2008·Genome Génome / Conseil National De Recherches Canada·Jennifer M CampbellWan L Lam

❮ Previous
Next ❯

Citations

Oct 7, 2017·ILAR Journal·Laura A CoxJohn L VandeBerg

❮ Previous
Next ❯

Software Mentioned

PEDSYS
SOLAR

Related Concepts

Related Feeds

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.