Quantitative magnetic resonance image analysis of the cerebellum in macrocephalic and normocephalic children and adults with autism.

Journal of the International Neuropsychological Society : JINS
Howard B CleavingerJanet E Lainhart

Abstract

A detailed morphometric analysis of the cerebellum in autism with and without macrocephaly. Four subject groups (N = 65; male; IQs > or = 65; age 7 to 26 years) were studied with quantitative MRI; normocephalic and macrocephalic individuals with autism without mental retardation were compared to normocephalic and benign macrocephalic typically developing individuals. Total cerebellum volumes and surface areas of four lobular midsagittal groups were measured. Independent t-tests between autism and control subjects matched for head size revealed no significant differences. Multivariate analyses of variance were also performed, using the diagnostic group as the fixed factor, cerebellar measures as the dependent variables and total intracranial volume, total brain volume, age, verbal IQ, and performance IQ as covariates. No significant differences were found; however, a trend was noted in which macrocephalic individuals with autism consistently exhibited slightly smaller cerebellar volume or surface area when compared to individuals with benign macrocephaly. In autism, with and without macrocephaly, cerebellar structures were found to be proportional to head size and did not differ from typically developing subjects.

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Citations

Aug 4, 2010·Archives of General Psychiatry·Matthew W MosconiJohn A Sweeney
Jun 6, 2009·Journal of Autism and Developmental Disorders·Xiaofei FanGang Yao
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Nov 11, 2014·The Cerebellum·Leonardo BaldarçaraChristophe Habas
Nov 4, 2009·Journal of Autism and Developmental Disorders·Elgiz BalStephen W Porges
May 6, 2014·Frontiers in Human Neuroscience·Kelly MichaelisJames C Thompson
Dec 6, 2019·Translational Psychiatry·Amy E Clipperton-AllenDamon T Page
May 24, 2020·The Cerebellum·Joel CrucittiMark A Stokes

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