Quantitative magnetic resonance spectroscopy at 3T based on the principle of reciprocity

NMR in Biomedicine
Niklaus ZoelchAnke Henning

Abstract

Quantification of magnetic resonance spectroscopy signals using the phantom replacement method requires an adequate correction of differences between the acquisition of the reference signal in the phantom and the measurement in vivo. Applying the principle of reciprocity, sensitivity differences can be corrected at low field strength by measuring the RF transmitter gain needed to obtain a certain flip angle in the measured volume. However, at higher field strength the transmit sensitivity may vary from the reception sensitivity, which leads to wrongly estimated concentrations. To address this issue, a quantification approach based on the principle of reciprocity for use at 3T is proposed and validated thoroughly. In this approach, the RF transmitter gain is determined automatically using a volume-selective power optimization and complemented with information from relative reception sensitivity maps derived from contrast-minimized images to correct differences in transmission and reception sensitivity. In this way, a reliable measure of the local sensitivity was obtained. The proposed method is used to derive in vivo concentrations of brain metabolites and tissue water in two studies with different coil sets in a total of 40 hea...Continue Reading

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Citations

Feb 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saipavitra Murali-ManoharAnke Henning
Jul 1, 2020·Molecular Psychiatry·Etna J E EngeliMarcus Herdener
Dec 28, 2021·Journal of Magnetic Resonance Imaging : JMRI·Bijaya ThapaOvidiu C Andronesi

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