Quantitative measurement of protease ligand conformation.

Journal of Computer-aided Molecular Design
Christopher J R IllingworthChristopher A Reynolds

Abstract

The tendency for protease ligands to bind in an extended conformation has been suggested as an important factor for the identification of compounds of medicinal importance. Here we present a novel graph-theoretical method giving a quantitative measure of ligand conformation, and through application of this method to a representative set of protease ligands in bound and unbound conformations, derive the result that protease ligands are more extended in conformation when in their bound state.

References

Dec 28, 1999·Journal of Molecular Recognition : JMR·J D Tyndall, D P Fairlie
Aug 22, 2002·Journal of Computer-aided Molecular Design·David J Diller, Kenneth M Merz
Mar 10, 2005·Chemical Reviews·Joel D A TyndallDavid P Fairlie
Dec 31, 2005·Nucleic Acids Research·Neil D RawlingsAlan J Barrett

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