Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES)

Metallomics : Integrated Biometal Science
Matthew D HallTrevor W Hambley

Abstract

The platinum(II) drugs cisplatin, carboplatin and oxaliplatin are usefully employed against a range of malignancies, but toxicities and resistance have spurred the search for improved analogs. This has included investigation of the platinum(IV) oxidation state, which provides greater kinetic inertness. It is generally accepted that Pt(IV) complexes must be reduced to Pt(II) for activation. As such, the ability to monitor reduction of Pt(IV) complexes is critical to guiding the design of candidates, and providing mechanistic understanding. Here we report in full that the white line height of X-ray absorption near-edge spectra (XANES) of Pt complexes, normalized to the post-edge minima, can be used to quantitatively determine the proportion of each oxidation state in a mixture. A series of Pt(IV) complexes based on the Pt(II) complexes cisplatin and transplatin were prepared with chlorido, acetato or hydroxido axial ligands, and studies into their reduction potential and cytotoxicity against A2780 human ovarian cancer cells were performed, demonstrating the relationship between reduction potential and cytotoxicity. Analysis of white line height demonstrated a clear and consistent difference between Pt(II) (1.52 ± 0.05) and Pt(IV)...Continue Reading

References

Jul 1, 1984·Journal of Medicinal Chemistry·R J Brandon, J C Dabrowiak
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·W P PetrosD L Trump
Jan 8, 2000·Journal of Inorganic Biochemistry·T W HambleyS Rainone
Sep 23, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J HolfordL R Kelland
Mar 19, 2002·Journal of Inorganic Biochemistry·Rachael C DolmanTrevor W Hambley
Jun 19, 2003·Journal of the American Chemical Society·Matthew D HallTrevor W Hambley
Jul 3, 2007·Journal of Medicinal Chemistry·Matthew D HallTrevor W Hambley
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland
Mar 4, 2010·Chemical Communications : Chem Comm·Alina NemirovskiDan Gibson

❮ Previous
Next ❯

Citations

May 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Snežana JovanovićRudi van Eldik
Jun 22, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Jingran DongTiesheng Shi
Jun 22, 2016·Journal of Inorganic Biochemistry·Melani SooriyaarachchiGraham N George
Oct 19, 2016·Journal of Inorganic Biochemistry·Kaitlin A DoucetteDebbie C Crans
May 31, 2019·Chemical Communications : Chem Comm·Carlos Sanchez-CanoPeter J Sadler
May 1, 2015·Chemical Science·Daniel Yuan Qiang WongWee Han Ang
Mar 7, 2019·Metallomics : Integrated Biometal Science·Catherine K J ChenTrevor W Hambley
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mathilde BouchéStéphane Bellemin-Laponnaz
Oct 22, 2020·Metallomics : Integrated Biometal Science·Catherine K J ChenTrevor W Hambley
Nov 6, 2021·Journal of Synchrotron Radiation·George E Sterbinsky, Steve M Heald
Nov 23, 2021·Journal of the American Chemical Society·Elizabeth M BolithoPeter J Sadler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.