Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
V BusigniesP Tchoreloff

Abstract

Direct compaction is a complex process that results in a density distribution inside the tablets which is often heterogeneous. Therefore, the density variations may affect the compact properties. A quantitative analysis of this phenomenon is still lacking. Recently, X-ray microtomography has been successfully used in pharmaceutical development to study qualitatively the impact of tablet shape and break-line in the density of pharmaceutical tablets. In this study, we evaluate the density profile in microcrystalline cellulose (Vivapur 12) compacts obtained at different mean porosity (ranging from 7.7% to 33.5%) using X-ray tomography technique. First, the validity of the Beer-Lambert law is studied. Then, density calibration is performed and density maps of cylindrical tablets are obtained and visualized using a process with colour-scale calibration plot which is explained. As expected, important heterogeneity in density is observed and quantified. The higher densities in peripheral region were particularly investigated and appraised in regard to the lower densities observed in the middle of the tablet. The results also underlined that in the case of pharmaceutical tablets, it is important to differentiate the mechanical properti...Continue Reading

Citations

Jul 12, 2011·Pharmaceutical Research·Vishal KoradiaJukka Rantanen
Mar 31, 2011·Drug Development and Industrial Pharmacy·Sameh Abdel-Hamid, Gabriele Betz
Mar 11, 2009·Drug Development and Industrial Pharmacy·Yoshihiro TokudomeMakoto Otsuka
Jun 12, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Juha MönkäreKristiina Järvinen
Feb 23, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P R Laity, R E Cameron
Jan 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andres M Miguélez-MoránJonathan P K Seville
Mar 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Virginie BusigniesPierre Tchoreloff
Jul 23, 2015·International Journal of Pharmaceutics·Harona DiarraPierre Tchoreloff
Apr 8, 2015·Journal of Food Engineering·Shivangi KelkarMartin Okos
Jun 2, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kozo TakayamaYasuko Obata
Apr 9, 2019·Journal of the Royal Society, Interface·Shardul Atul BhusariBikramjit Basu
Nov 4, 2020·International Journal of Pharmaceutics·Xingxing LuHong-Liang Cui
Sep 25, 2018·Journal of Pharmaceutical Sciences·Naveen K ThakralRaj Suryanarayanan
Mar 5, 2021·Journal of Pharmaceutical Sciences·Shubhajit Paul, Yin-Chao Tseng
Sep 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K R Sneha, G S Sailaja

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