Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans

The Journal of the Acoustical Society of America
V P SpongrR J Salvi

Abstract

The CBA mouse shows little evidence of hearing loss until late in life, whereas the C57BL/6 strain develops a severe and progressive, high-frequency sensorineural hearing loss beginning around 3-6 months of age. These functional differences have been linked to genetic differences in the amount of hair cell loss as a function of age; however, a precise quantitative description of the sensory cell loss is unavailable. The present study provides mean values of inner hair cell (IHC) and outer hair cell (OHC) loss for CBA and C57BL/6 mice at 1, 3, 8, 18, and 26 months of age. CBA mice showed little evidence of hair cell loss until 18 months of age. At 26 months of age, OHC losses in the apex and base of the cochlea were approximately 65% and 50%, respectively, and IHC losses were approximately 25% and 35%. By contrast, C57BL/6 mice showed approximately a 75% OHC and a 55% IHC loss in the base of the cochlea at 3 months of age. OHC and IHC losses increased rapidly with age along a base-to-apex gradient. By 26 months of age, more than 80% of the OHCs were missing throughout the entire cochlea; however, IHC losses ranged from 100% near the base of the cochlea to approximately 20% in the apex.

References

Jan 1, 1991·Acta Oto-laryngologica·H S Li, E Borg
Nov 1, 1991·Hearing Research·G ShoneA L Nuttall
Sep 1, 1990·Hearing Research·B A BohneG W Harding
Jun 1, 1990·The Journal of the Acoustical Society of America·D D Greenwood
Jun 1, 1983·The Journal of the Acoustical Society of America·G EhretR R Capranica
Jun 11, 1982·Science·M C Liberman
Dec 1, 1982·Hearing Research·E M Keithley, M L Feldman
Mar 15, 1993·The Journal of Comparative Neurology·J F WillottS L McFadden
May 1, 1996·Hearing Research·D R TruneC Mitchell

❮ Previous
Next ❯

Citations

Dec 31, 2010·Experimental Brain Research·Americo A MigliaccioCharles C Della Santina
Jun 5, 2003·Journal of the Association for Research in Otolaryngology : JARO·James R Ison, Paul D Allen
Jun 29, 2005·Journal of the Association for Research in Otolaryngology : JARO·James F WillottSandra McFadden
Apr 25, 2007·Journal of the Association for Research in Otolaryngology : JARO·Martha L ZettelRobert D Frisina
Nov 13, 2007·Journal of the Association for Research in Otolaryngology : JARO·Joseph P WaltonWillard W Wilson
Aug 14, 2010·Journal of the Association for Research in Otolaryngology : JARO·Kevin K OhlemillerPatricia M Gagnon
Nov 6, 2010·Journal of the Association for Research in Otolaryngology : JARO·Bruce MockSherri M Jones
May 26, 2004·Hearing Research·Patricia GuimaraesRobert D Frisina
Aug 30, 2000·Hearing Research·J C MilbrandtD M Caspary
Jul 18, 2002·Hearing Research·Kevin K OhlemillerMark S Sands
Nov 16, 2002·Hearing Research·Yoko KitamuraTsutomu Nakashima
Sep 19, 2003·Hearing Research·Cynthia A ProsenBradford J May
Nov 27, 1999·Hearing Research·A M JimenezB L Lonsbury-Martin
Feb 15, 2001·Nature Genetics·K R JohnsonN Fischel-Ghodsian
Nov 19, 2011·Experimental Aging Research·Matthew J Sanders
Jul 26, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Thijs T G JansenWilko Grolman
Aug 24, 2007·Audiology & Neuro-otology·Michael Anne GrattonJames C Saunders
Jun 12, 2013·PloS One·Zhongping MaoDavid Z Z He
Aug 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yevgeniya SergeyenkoSharon G Kujawa
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hainan LangRichard A Schmiedt
Feb 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharon G Kujawa, M Charles Liberman
Jun 25, 2014·Clinical Interventions in Aging·Grażyna LisowskaMaciej Misiolek
Aug 1, 2006·The Journal of the Acoustical Society of America·Bradford J MayCynthia A Prosen
Sep 2, 2014·Experimental Gerontology·Moritz GröschelDietmar Basta
Sep 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mingqian HuangZheng-Yi Chen
Aug 16, 2003·International Journal of Audiology·Theresa Hnath ChisolmJennifer J Lister
Jan 24, 2016·Experimental Gerontology·Jiaqi PangYiqing Zheng
Feb 3, 2015·Current Biology : CB·Emma N FloresJaime García-Añoveros
Sep 18, 2012·Experimental Gerontology·Natalia RybalkoJosef Syka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.