Quantitative measures of meniscus extrusion predict incident radiographic knee osteoarthritis--data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage
K EmmanuelD T Felson

Abstract

To test the hypothesis that quantitative measures of meniscus extrusion predict incident radiographic knee osteoarthritis (KOA), prior to the advent of radiographic disease. 206 knees with incident radiographic KOA (Kellgren Lawrence Grade (KLG) 0 or 1 at baseline, developing KLG 2 or greater with a definite osteophyte and joint space narrowing (JSN) grade ≥1 by year 4) were matched to 232 control knees not developing incident KOA. Manual segmentation of the central five slices of the medial and lateral meniscus was performed on coronal 3T DESS MRI and quantitative meniscus position was determined. Cases and controls were compared using conditional logistic regression adjusting for age, sex, BMI, race and clinical site. Sensitivity analyses of early (year [Y] 1/2) and late (Y3/4) incidence was performed. Mean medial extrusion distance was significantly greater for incident compared to non-incident knees (1.56 mean ± 1.12 mm SD vs 1.29 ± 0.99 mm; +21%, P < 0.01), so was the percent extrusion area of the medial meniscus (25.8 ± 15.8% vs 22.0 ± 13.5%; +17%, P < 0.05). This finding was consistent for knees restricted to medial incidence. No significant differences were observed for the lateral meniscus in incident medial KOA, or fo...Continue Reading

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Citations

Oct 19, 2016·Current Opinion in Rheumatology·Win M OoDavid J Hunter
Dec 25, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomohiko MatsuoMasayuki Hamada
Jan 28, 2017·The American Journal of Sports Medicine·Nam-Ki KimJae-Hyan Kim
May 19, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhaoye ZhouFang Liu
Feb 15, 2019·The American Journal of Sports Medicine·Sang-Min LeeJun-Gu Park
May 20, 2020·Radiology·Frank W RoemerAli Guermazi
Sep 7, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Lukas WillingerAndrea Achtnich
May 23, 2019·BMC Musculoskeletal Disorders·Matthew S HarkeyJeffrey B Driban
Dec 23, 2017·The British Journal of Radiology·Daichi HayashiAli Guermazi
Jan 5, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Katrin KarpinskiWolf Petersen
Aug 1, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomoharu MochizukiNaoto Endo
Oct 23, 2020·Pain·Tonia L Vincent
Apr 29, 2021·Archives of Orthopaedic and Trauma Surgery·Silvampatti Ramsamy SundararajanShanmuganathan Rajasekaran
Jun 18, 2021·Radiology. Artificial Intelligence·Hesham Elhalawani, Raymond Mak
Jul 9, 2021·Radiology. Artificial Intelligence·Arjun D DesaiUNKNOWN IWOAI Segmentation Challenge Writing Group
Aug 17, 2021·Sports Medicine and Arthroscopy Review·Michael D BedrinJonathan F Dickens
Aug 21, 2021·The American Journal of Sports Medicine·Kazuya NishinoHiroaki Nakamura
Nov 20, 2021·The American Journal of Sports Medicine·Ding-Yu WangJia-Kuo Yu

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