Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy

Arthritis and Rheumatism
Peter P YoussefPaul P Tak

Abstract

To evaluate microscopic measures of inflammation in rheumatoid arthritis synovial tissue samples selected at arthroscopy compared with those obtained blindly by needle biopsy from the suprapatellar pouch (SPP) of the same joint. Samples were selected at knee arthroscopy from the SPP and the lateral and medial gutters. Immediately following arthroscopy, a biopsy needle was inserted through the same portal into the SPP by a second investigator, and 3 further samples were obtained blindly. Using standard immunohistologic methods, all samples were analyzed by a single investigator without knowledge of the original tissue location and biopsy technique. Following staining with anti-CD3 and anti-CD68 monoclonal antibodies, T lymphocyte and macrophage infiltration were measured by quantitative analysis. Synovial tissues from 14 patients were analyzed. In comparing microscopic measures of inflammation using the 2 procedures, mean scores of lining cell depth and the percentage of CD68+ cells in the lining layer correlated positively (tau = 0.59, P = 0.003 and tau = 0.73, P = 0.0003, respectively). In the sublining layer, CD3+ cell counts also correlated significantly (tau = 0.71, P = 0.0004). Sublining CD68+ cell counts did not correlate...Continue Reading

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Citations

Jun 9, 2005·Best Practice & Research. Clinical Rheumatology·Danielle Gerlag, Paul P Tak
Jun 5, 2013·Best Practice & Research. Clinical Rheumatology·Daniëlle M Gerlag, Paul P Tak
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·A J M SchuerweghR E M Toes
May 23, 2008·Rheumatology·G MurphyM Molloy
Jun 15, 2004·Annals of the Rheumatic Diseases·J A SinghH R Schumacher
Feb 26, 2005·Annals of the Rheumatic Diseases·M J BenitoB Bresnihan
Jun 25, 2005·Annals of the Rheumatic Diseases·M D SmithUNKNOWN OMERACT synovial special interests group
May 5, 2010·Annals of the Rheumatic Diseases·C T NgD J Veale
Nov 23, 2000·Annals of the Rheumatic Diseases·P P Tak
Jun 30, 2000·Annals of the Rheumatic Diseases·B BresnihanF Breedveld
May 19, 2005·Arthritis Research & Therapy·René J BerckmansPaul P Tak
Dec 1, 2006·Arthritis Research & Therapy·Johan LindbergJoakim Lundeberg
Jun 6, 2009·Arthritis Research & Therapy·Erik af KlintStaffan Lindblad
Dec 3, 2009·Arthritis Research & Therapy·Stefan VordenbäumenBenedikt Ostendorf
Nov 30, 2000·Arthritis Research·P P Tak, F C Breedveld
Apr 28, 2009·Best Practice & Research. Clinical Rheumatology·Daniëlle M Gerlag, Paul P Tak
Aug 3, 2007·The Journal of Investigative Dermatology·Marina O'KaneEvelyn P Murphy
Apr 13, 2011·Arthritis and Rheumatism·Monika BinieckaJacintha O'Sullivan
May 23, 2006·Journal of the American Academy of Dermatology·Trevor MarkhamDouglas J Veale
Aug 27, 2014·Arthritis & Rheumatology·Monika BinieckaUrsula Fearon
May 19, 2001·Best Practice & Research. Clinical Rheumatology·P P Tak
Aug 2, 2012·Ultrastructural Pathology·Li Yun ZhangH Ralph Schumacher
Nov 28, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·A Fraser, D J Veale
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·B Bresnihan, P P Tak
Oct 28, 2016·International Journal of Rheumatic Diseases·Ved ChaturvediPatrick D W Kiely
Jul 14, 2017·Nature Reviews. Rheumatology·Carl OrrSander W Tas
Jul 13, 2002·Arthritis and Rheumatism·Agustín Escalante, Inmaculada Del Rincón

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