Quantitative modeling of tumor dynamics and radiotherapy.

Acta Biotheoretica
Heiko EnderlingPhilip Hahnfeldt

Abstract

Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localize...Continue Reading

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Citations

Jan 3, 2012·Theoretical Biology & Medical Modelling·Charles I MortonHeiko Enderling
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Jun 9, 2021·International Journal of Radiation Oncology, Biology, Physics·Mohammad U ZahidHeiko Enderling

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