PMID: 3748270Jul 1, 1986Paper

Quantitative morphology of medium-sized caudate spiny neurons in aged cats

Neurobiology of Aging
M S LevineJ P McAllister

Abstract

These studies were designed to assess some of the morphological alterations that occur in medium-sized spiny neurons of the caudate nucleus in aged cats. Computer assistance was used to quantify in three dimensions the extent of the dendritic trees of 164 neurons from 11 cats (5 1-3 years and 6 over 10 years of age) stained by the rapid Golgi technique. In all animals beyond 10 years of age there was a decrease in the density of spines on distal dendritic segments. This decrease was moderate (16%) in 13 year old cats and reached about 50% in 15 and 18 year old animals. In addition, there was an increase in the frequency of occurrence of spines with enlarged heads in all aged cats. In cats over 13 years there was a marked loss of portions of distal dendritic segments. All measures of dendrite length displayed statistically significant decreases of 30-40% in cats 15 and 18 years of age. There were no significant age-related alterations in numbers of dendrites, number of branches per dendrite or soma diameter. These morphological results indicate that there is a sequence of age-related changes that occurs in caudate medium-sized spiny neurons and provides a basis from which to assess functional alterations.

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Citations

Feb 9, 1988·Brain Research·M S LevineN A Buchwald
May 1, 1987·Neurobiology of Aging·M S LevineN A Buchwald
Dec 3, 2014·The Veterinary Clinics of North America. Small Animal Practice·Charles H Vite, Elizabeth Head
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Jul 10, 2007·The Journal of Small Animal Practice·D Gunn-MooreE Head
Nov 22, 2005·Neurobiology of Aging·Tianmiao HuaAudie G Leventhal
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Jul 30, 2014·Frontiers in Aging Neuroscience·Zhengchun WangYifeng Zhou
Jan 1, 1988·Annals of the New York Academy of Sciences·M S Levine
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Khader M HasanPonnada A Narayana
Jun 27, 2019·Journal of Neuroscience Research·John P Walsh, Garnik Akopian
Oct 4, 2021·Mechanisms of Ageing and Development·Yana BlinkouskayaJohannes Weickenmeier

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