Quantitative MR in multi-center clinical trials

Journal of Magnetic Resonance Imaging : JMRI
Edward Ashton

Abstract

MRI has a wide variety of applications in the clinical trials process. MR has shown particular utility in the early phases of clinical development, when trial sponsors are interested in demonstrating proof of concept and must make decisions about allocation of resources to a particular compound based on the results from a small number of experimental subjects. This utility is largely due to the many different imaging endpoints that can be measured using MR, ranging from structural (tumor burden, hippocampal volume) to functional (blood flow, vascular permeability) to molecular (hepatic fat fraction, glycosaminoglycan content). The unique flexibility of these systems has proven to be both a blessing and a curse to those attempting to deploy MR in multi-center clinical trials, however, as differences among scanner manufacturers and models in pulse sequence implementation, hardware capabilities, and even terminology make it increasingly difficult to ensure that results obtained at one center are comparable to those at another. These problems are compounded by the differences between the procedures used in clinical trials and those used in routine clinical practice, which make trial-specific training for site technologists and radi...Continue Reading

References

Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·P S Tofts
Nov 14, 1997·Radiology·B J DardzinskiM B Smith
Mar 10, 1998·AJR. American Journal of Roentgenology·F EcksteinM Reiser
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·J L Evelhoch
Feb 16, 2000·Biomaterials·J S Temenoff, A G Mikos
Jan 25, 2002·Current Controlled Trials in Cardiovascular Medicine·Steven Warach
Mar 1, 2002·NMR in Biomedicine·Anwar R PadhaniMartin O Leach
Sep 5, 2002·Arthritis and Rheumatism·Anita E WlukaFlavia M Cicuttini
Jan 3, 2003·The New England Journal of Medicine·David H MillerUNKNOWN International Natalizumab Multiple Sclerosis Trial Group
Feb 21, 2003·Journal of Magnetic Resonance Imaging : JMRI·Edward A AshtonSven Ekholm
Feb 21, 2003·Journal of Magnetic Resonance Imaging : JMRI·Cynthia F MaierHollis G Potter
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl Johan TideriusLeif Dahlberg
Jun 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen L AndersonPatricia M Price
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenya Murase
Jun 3, 2004·Magnetic Resonance Imaging·Eve David-VaudeySharmila Majumdar
Oct 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G C JaysonA Jackson
Apr 6, 2005·Archives of General Psychiatry·Jeffrey A LiebermanUNKNOWN HGDH Study Group
Apr 27, 2005·Nature Medicine·Mark H TuszynskiJames Conner
May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstAlan Sandler
May 21, 2005·Journal of Magnetic Resonance Imaging : JMRI·Baocheng ChuChun Yuan
Jun 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Klaus MrossClemens Unger
Jul 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jerry M Collins
Aug 11, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott B ReederNorbert J Pelc
Nov 30, 2005·Journal of Magnetic Resonance Imaging : JMRI·Rebecca Rakow-PennerGary H Glover
Jan 24, 2006·Investigative Radiology·Tali KimelmanPottumarthi Prasad
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Peter MarckmannHenrik S Thomsen
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Luke FuD Louis Collins
Dec 8, 2007·Journal of Magnetic Resonance Imaging : JMRI·Clare P BernardChristian M Langton
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael W Weiner

❮ Previous
Next ❯

Citations

Feb 16, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Ralph P MasonKevin G Pinney
Jan 6, 2011·Schizophrenia Bulletin·Caroline SchusterJack René Foucher
Mar 11, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Marijn P RolfRob M Heethaar
Oct 15, 2013·Journal of Magnetic Resonance Imaging : JMRI·Henk SmitGyula Kotek
Sep 13, 2017·Scientific Reports·UNKNOWN Joint Head and Neck Radiotherapy-MRI Development Cooperative
Jul 2, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gwendolyn Van SteenkisteJan Sijbers
Sep 19, 2018·BMC Medical Imaging·Michael E OsadebeyFor The Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved