Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury

NeuroImage. Clinical
Maryam SeifPatrick Freund

Abstract

To reveal the immediate extent of trauma-induced neurodegenerative changes rostral to the level of lesion and determine the predictive clinical value of quantitative MRI (qMRI) following acute spinal cord injury (SCI). Twenty-four acute SCI patients and 23 healthy controls underwent a high-resolution T1-weighted protocol. Eighteen of those patients and 20 of controls additionally underwent a multi-parameter mapping (MPM) MRI protocol sensitive to the content of tissue structure, including myelin and iron. Patients were examined clinically at baseline, 2, 6, 12, and 24 months post-SCI. We assessed volume and microstructural changes in the spinal cord and brain using T1-weighted MRI, magnetization transfer (MT), longitudinal relaxation rate (R1), and effective transverse relaxation rate (R2*) maps. Regression analysis determined associations between acute qMRI parameters and recovery. At baseline, cord area and its anterior-posterior width were decreased in patients, whereas MT, R1, and R2* parameters remained unchanged in the cord. Within the cerebellum, volume decrease was paralleled by increases of MT and R2* parameters. Early grey matter changes were observed within the primary motor cortex and limbic system. Importantly, ear...Continue Reading

Citations

Oct 22, 2020·Journal of Neurophysiology·Simon HenmarRune W Berg
Jan 7, 2021·Neurospine·José Antonio Soriano SánchezMehmet Zileli
Apr 14, 2021·Brain Research Bulletin·Hamid Soltani ZangbarMohsen Jafarzadehgharehziaaddin
Jun 17, 2021·Human Brain Mapping·Vincent HuynhLars Michels
Jul 17, 2021·Current Neurology and Neuroscience Reports·Simon SchadingPatrick Freund
Oct 8, 2021·Current Opinion in Neurology·Dario Pfyffer, Patrick Freund

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