Quantitative MRI Reveals Microstructural Changes in the Upper Leg Muscles After Running a Marathon

Journal of Magnetic Resonance Imaging : JMRI
Melissa T HooijmansGustav J Strijkers

Abstract

The majority of sports-related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to acute symptoms, exercise-induced microtrauma may remain subclinical and difficult to detect. Therefore, novel methods to detect and localize subclinical exercise-induced muscle microtrauma are desirable. To assess acute and delayed microstructural changes in upper leg muscles with multiparametric quantitative MRI after running a marathon. Longitudinal; 1-week prior, 24-48 hours postmarathon and 2-week follow-up POPULATION: Eleven men participants (age: 47-68 years). Spin-echo echo planar imaging (SE-EPI) with diffusion weighting, multispin echo, Dixon, and fat-suppressed turbo spin-echo (TSE) sequences at 3T. MR datasets and creatine kinase (CK) concentrations were obtained at three timepoints. Diffusion parameters, perfusion fractions, and quantitative (q)T2 values were determined for hamstring and quadriceps muscles, TSE images were scored for acute injury. The vastus medialis and biceps femoris long head muscles were divided and analyzed in five segments to assess local damage. Differences between timepoints in MR parameters were assessed with a multilevel linear mixed model and i...Continue Reading

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Citations

Mar 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Matthew F KoffDarryl B Sneag
Mar 5, 2021·Frontiers in Neurology·Valentina MazzoliGarry E Gold

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