PMID: 10775855Apr 25, 2000Paper

Quantitative nailfold capillary microscopy findings in patients with acrocyanosis compared with patients having systemic sclerosis and control subjects

Journal of the American Academy of Dermatology
G MonticoneP Puddu

Abstract

The morphologic capillary microscopy (capillaroscopy) pattern of acrocyanosis is characterized by hemorrhages, pericapillary edema, and widened capillaries. These findings can result in a difficult differential diagnosis with systemic sclerosis (SSc). We sought to quantify the characteristics of the capillaroscopy pattern that distinguishes patients with acrocyanosis from patients with SSc and control subjects. A videomicroscope with fiberoptic illumination and personal computer-based image processing was used to measure capillary density, giant capillaries, loop width, and arterial and venous limbs in 10 patients with acrocyanosis, 10 patients with SSc, and 10 healthy control subjects. Acrocyanotic patients differed in every quantitative parameter both from control subjects and patients with SSc. In particular, capillary density, which was reduced compared with that of control subjects, was much higher than that of patients with SSc: one giant capillary per finger was observed in 2 patients with acrocyanosis, whereas more than 2 giant capillaries per finger were observed in each patient with SSc. These differences may aid in making the distinction between the capillaroscopy patterns in acrocyanosis and SSc.

References

Sep 1, 1986·Annals of the Rheumatic Diseases·F Lefford, J C Edwards
Jan 1, 1997·Cardiovascular Research·J Belch
Nov 1, 1995·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S SeidenariB Belletti

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Citations

Jun 14, 2005·Clinical Rheumatology·Madeleine MeliBeatrice R Amann-Vesti
Oct 29, 2013·BioMed Research International·Agnieszka GerkowiczGrażyna Chodorowska
Jul 17, 2007·Clinical Rheumatology·Walter Grassi, Rossella De Angelis
Mar 24, 2011·Vascular Medicine·Andrew K KurklinskyThom W Rooke
Dec 18, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·Z Nagy, L Czirják
Feb 28, 2009·Arthritis and Rheumatism·Rossella De AngelisMaurizio Cutolo
Feb 11, 2021·Vascular Medicine·Eunjung Choi, Stanislav Henkin
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Thomas Grader-Beck, Fredrick M Wigley
Apr 8, 2006·Microvascular Research·Kenneth M ChrobakJoe Tien

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