PMID: 9177231Jun 10, 1997Paper

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy

Proceedings of the National Academy of Sciences of the United States of America
L L ChengR Gilberto Gonzalez

Abstract

We describe a method that directly relates tissue neuropathological analysis to medical imaging. Presently, only indirect and often tenuous relationships are made between imaging (such as MRI or x-ray computed tomography) and neuropathology. We present a biochemistry-based, quantitative neuropathological method that can help to precisely quantify information provided by in vivo proton magnetic resonance spectroscopy (1HMRS), an emerging medical imaging technique. This method, high resolution magic angle spinning (HRMAS) 1HMRS, is rapid and requires only small amounts of unprocessed samples. Unlike chemical extraction or other forms of tissue processing, this method analyzes tissue directly, thus minimizing artifacts. We demonstrate the utility of this method by assessing neuronal damage using multiple tissue samples from differently affected brain regions in a case of Pick disease, a human neurodegenerative disorder. Among different regions, we found an excellent correlation between neuronal loss shown by traditional neurohistopathology and decrease of the neuronal marker N-acetylaspartate measured by HRMAS 1HMRS. This result demonstrates for the first time, to our knowledge, a direct, quantitative link between a decrease in N-...Continue Reading

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Citations

Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·John KurhanewiczDaniel B Vigneron
Apr 30, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jian Zhi HuRobert A Wind
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jin-Hong ChenSamuel Singer
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S GarrodE Holmes
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Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P WeybrightS Singer
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Aug 21, 2007·Pediatric Radiology·Ali Yusuf OnerAyse Serdaroglu
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