Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

Skeletal Radiology
Sven NebelungDaniel Truhn

Abstract

To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Human osteochondral samples of variable degeneration (n = 45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1ρ, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical homogeneity index]) and attenuation (OAI, optical attenuation index]). Samples were also assessed macroscopically (Outerbridge classification) and histologically (Mankin classification) as grade-0 (Mankin scores 0-4)/grade-I (scores 5-8)/grade-II (scores 9-10)/grade-III (score 11-14). After data normalisation, differences between Mankin grades and correlations between imaging parameters were assessed using ANOVA and Tukey's post-hoc test and Spearman's correlation coefficients, respectively. Sensitivities and specificities in the detection of Mankin grade-0 were calculated. Significant degeneration-related increases were found for T2 and OII and decreases for OAI, while T1, T1ρ, T2* or OHI did not reveal significant changes in relation to ...Continue Reading

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Citations

Oct 21, 2016·Skeletal Radiology·Sven NebelungDaniel Truhn
Jul 8, 2017·Biomechanics and Modeling in Mechanobiology·Sven NebelungDaniel Truhn
Jul 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yoshihisa KushidaIchiro Sekiya
Sep 25, 2017·Der Orthopäde·S NebelungS Schrading
May 7, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Daniel TruhnSven Nebelung

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